A 25 year old woman presents to your clinic with carcinoma of her right breast. Her sister was also diagnosed with breast carcinoma at age of 28. Her father suffered from myxofibrosarcoma and her younger brother died at age 5 with medulloblastoma. She has a nephew aged 8, who suffers from rhabdomyosarcoma.
This pedigree illustrates
a. genetic heterogenicity
b. incomplete penetrance
c. multifactorial inheritance
d. variable expressivity
well, its just that non of the options make perfect sense. The family is packed with a a bunch of malignancies so I think one of the familial cancer syndromes like Li Freumani Syndrome (p53 mutation) is involved. Therefore I don't think it is multifactorial. But I am confused between a. genetic heterogenicity and b. variable expressivity.
A 25 year old woman presents to your clinic with carcinoma of her right breast. Her sister was also diagnosied with breast carcinoma at age of 28. Her father suffered from myxofibrosarcoma and her younger brother died at age 5 with medulloblastoma. She has a nephew aged 8, who suffers from rhabdomyosarcoma.
This pedigree illustrates
a.genetic heterogenicity
b. incomplete penetrance
c. multifactorial inheritance
d. variable expressivity
I think it would be variable expressivity
As genetic heterogenicity would be something like different alleles causing single disorder.
Whereas this case look like p53 mutation.
Other options are less probable.
wouldn't variable expressivity mean different phenotypic types for the same genetic disease?
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