Hi all,
help me please to make clear some things.
The question: A monoclonal IgG ab directed against the HA of influenza A virus acts to neutralize the binding of the virus to the target cells. A second IgG ab is made against the idiotype region of the first ab, and it inhibits viral infection. Which of the following is most likely recognized by the IgG anti-idiotype ab?
Of course we know that HA works against sialic acid, so correct answer will be "Sialic acid"
Explanation (if you need): An anti-id ab is directed against the portion of the ab that recognized the original antigen and in many ways will resemble the original antigen. Sialic acid is the receptor for influenza virus. Because the original ab prevents the binding of HA to sialic acid, the anti-id won't to HA. Binding to complement is a normal property of IgG. By difinition, the anti-id will bind to the anti-HA, because anti-HA was the immunogen to which the anti-id was made.
My questions: I didn't understand which region of "second" ab has receptor to sialic acid (is it site for binding to FC receptors)? Because if it would be a abtigen-binding site it could be immunologic reacton...
Why we need ABs with "sialic acid" like binding shape? How it can help with influenza infection?
help me please to make clear some things.
The question: A monoclonal IgG ab directed against the HA of influenza A virus acts to neutralize the binding of the virus to the target cells. A second IgG ab is made against the idiotype region of the first ab, and it inhibits viral infection. Which of the following is most likely recognized by the IgG anti-idiotype ab?
Of course we know that HA works against sialic acid, so correct answer will be "Sialic acid"
Explanation (if you need): An anti-id ab is directed against the portion of the ab that recognized the original antigen and in many ways will resemble the original antigen. Sialic acid is the receptor for influenza virus. Because the original ab prevents the binding of HA to sialic acid, the anti-id won't to HA. Binding to complement is a normal property of IgG. By difinition, the anti-id will bind to the anti-HA, because anti-HA was the immunogen to which the anti-id was made.
My questions: I didn't understand which region of "second" ab has receptor to sialic acid (is it site for binding to FC receptors)? Because if it would be a abtigen-binding site it could be immunologic reacton...
Why we need ABs with "sialic acid" like binding shape? How it can help with influenza infection?