He discuss how to calculate prevalence if carrier rate is given .i just posted as i saw prevalence and carrier rate,so posted ..........so it cant be used here or is this forumula only for AD ?
If q is 1/1,000,000 or whatever than p is 999,999/1,000,000 no matter how low is q, bare in mind that p is always 1-q. So carrier frequency will be 2x(1-q)xq you can choose the closest answer option to your value. Practice this and then when u see the logic u can assume the p is 1 or very close to it when q is extremely low.
But in cas of CF let's say in Norway, q will be around 1/5...
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