A girl born to parents of eastern Mediterranean Jewish descent is brought to the pediatric neurology clinic. She appeared normal at birth and is now 6 months of age. There is a loss of peripheral vision and an abnormal startle response to auditory stimuli. She has suddenly shown a loss of coordination and has lost some responsiveness to her environment. She has a cherry-red spot on her macula. Treatments to cure this disease might focus on developing therapies that would do which one of the following?
A.
Stimulate ganglioside GM2 production
B.
Stimulate synthesis of GM2 by the rough endoplasmic reticulum (RER)
C.
Stimulate hexosaminidase production
D.
Stimulate transport of ganglioside GM2 to the lysosome
E.
Remove mannose 6-phosphate from hexosaminidase
A.
Stimulate ganglioside GM2 production
B.
Stimulate synthesis of GM2 by the rough endoplasmic reticulum (RER)
C.
Stimulate hexosaminidase production
D.
Stimulate transport of ganglioside GM2 to the lysosome
E.
Remove mannose 6-phosphate from hexosaminidase