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  #1  
Old 06-07-2011
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Drug some facts about lithium

Hey guys just trying to put up some effects of lithium as far as i studied

LITHIUM

1) lithium is used as mood stabilizer

2) lithium causes hypercalcemia ----->shifts Ca/PTH curve to right

3) lithium causes hypothyroidism

i would appreciate if someone will add other HY points
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  #2  
Old 06-07-2011
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Drug

Lithium can also cause torsades de pointes.

Symptoms of lithium toxicity include tremors, weakness, ataxia, AMS, nausea, vomiting, diarrhea, hypotension, leukocytosis, nephrotoxicity.

tx: hemodialysis if blood level is >2
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Old 06-08-2011
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some important facts about lithium:
  • Maternal use of lithium is linked with fetal ebstein's anomaly
  • lithium is contraindicated in breast feeding women
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Old 06-08-2011
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i would like to add that Lithium prevent recycling of inositol=>dec.IP3 and DAG
and it also Dec. cAMP...so it can lead to Hypothyroidism and nephrogenic DI because TSH and ADH both are Gs coupled..
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Old 06-13-2011
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Lithium

"LMNOPQST"

L = Lithium
M = Movement (tremor)
N = Nephrogenic DI (V2 receptor, which is Gs) / Narrow therapeutic index
O = hipOthyroidism (TSH act in a Gs receptor)
P = Pregnancy problems (Ebstein)
Q = inhibits Gq due to the fact that decrease IP3 (dec. IP2 & DAG)
S = inhibits Gs due to the fact that decrease AMPc / Seizures
T = Torsades de pointes
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