List of Drugs that prolong QT Interval - USMLE Forums
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Old 01-02-2012
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Drug List of Drugs that prolong QT Interval

Here are some drugs that prolong the QT (With a simple introduction/reference). I hope that it can help you in some way:

Class III antiarrhythmic: inhibition of potassium channels, can lead to ventricular tachyarrythmias.

Erythromycin: macrolide antibiotic, and is often used for people who have an allergy to penicillins. Better coverage of atypical organisms, including mycoplasma and Legionellosis.

Clarithromicin: macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydia pneumoniae or TWAR), skin and skin structure infections. In addition, it is sometimes used to treat Legionellosis, Helicobacter pylori, and lyme disease.

Pentamidine: Pentamidine is an antimicrobial medication given for prevention and treatment of Pneumocystis pneumonia (PCP). Also the mainstay of treatment for stage I infection with Trypanosoma brucei gambiense (West African Trypanosomiasis).

Moxifloxacin: is a fourth-generation synthetic fluoroquinolone antibacterial agent. This drug can lead to spontaneous tendon ruptures and worsening of myasthenia gravis symptoms, including muscle weakness and breathing problems. It is used to treat respiratory tract infections, cellulitis, anthrax, intraabdominal infections, endocarditis, meningitis, and tuberculosis.

Levofloxacin: is a fluoroquinolone used to treat infections including: respiratory tract infections, cellulitis, urinary tract infections, prostatitis, anthrax, endocarditis, meningitis, pelvic inflammatory disease, and traveler's diarrhea. Can also cause spontaneous tendon ruptures.

Imipramide: is an antidepressant medication, a tricyclic antidepressant of the dibenzazepine group. Imipramine is mainly used in the treatment of major depression and enuresis.

Desipramine: is a tricyclic antidepressant (TCA). It inhibits the reuptake of norepinephrine and to a lesser extent serotonin. It is used to treat depression, but not considered a first line treatment since the introduction of SSRI antidepressants. Desipramine is an active metabolite of imipramine.

Amitriptyline: is a tricyclic antidepressant (TCA). It is the most widely used TCA and has at least equal efficacy against depression as the newer class of SSRIs. As well as reducing depressive symptoms, these type of tricyclics also ease migraines, tension headaches, anxiety attacks and some schizophrenic symptoms.

Doxepin: is a psychotropic agent with tricyclic antidepressant and anxiolytic properties. Doxepin is used to treat depression, anxiety disorders, and as a second line treatment of chronic idiopathic urticaria. It is also used to treat insomnia.

Thioridazine: is an antipsychotic drug belonging to the phenothiazine drug group. Due to concerns about cardiotoxicity and retinopathy, this drug is reserved for patients who have failed to respond to, or have contraindications for, more widely used antipsychotics. A serious side effect is the potentially fatal neuroleptic malignant syndrome. It exerts its actions through a central adrenergic-blocking, a dopamine-blocking, and minor anticholinergic activity.

Haloperidol: is a typical antipsychotic. Haloperidol is an older antipsychotic used in the treatment of schizophrenia and, more acutely, in the treatment of acute psychotic states and delirium.

Risperidone: is a second generation or atypical antipsychotic. It is used to treat schizophrenia (including adolescent schizophrenia), schizoaffective disorder, the mixed and manic states associated with bipolar disorder, and irritability in people with autism. It is associated with significant weight gain and metabolic problems, as well as tardive dyskinesia and neuroleptic malignant syndrome. Risperidone and other antipsychotics also increase the risk of death in patients with dementia.

Ziprasidone: is an atypical antipsychotic approved for the treatment of schizophrenia and acute agitation in schizophrenic patients. Ziprasidone has also received approval for acute treatment of mania and mixed states associated with bipolar disorder.

Quetiapine: is an atypical antipsychotic approved for the treatment of schizophrenia, and bipolar disorder.

Fluconazole and itraconazole are known to inhibit drug metabolism, leading to large increase in plasma drug concentration.

And there it is...

Have a nice week!!!
"Disease is very old, and nothing about it has changed. It is we who change as we learn to recognize what was formerly imperceptible." JMC
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Old 01-03-2012
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Also Ondansetron, Ciprofloxacin, and Tacrolimus
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