21 versus 11 beta hydroxylase deficiencies - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum > USMLE Step 1 High Yield > USMLE Step 1 Bits & Pieces

USMLE Step 1 Bits & Pieces High yield short focused points, monographs, charts, illustrations, tables, and other stuff related to the USMLE Step 1 Exam.

Thread Tools Search this Thread Display Modes
Old 08-15-2009
USMLE Forums Master
Steps History: 1+CK+CS+3
Posts: 3,263
Threads: 147
Thanked 4,956 Times in 1,563 Posts
Reputation: 5052
Arrow 21 versus 11 beta hydroxylase deficiencies

Why do we have hypotension and increased angiotensin II in 21 b OH def
Why do we have hypertesion and decreased angiotensin II in 11 b OH def

The answer lies in 11-deoxycorticosterone:

this compound which is a mineralocorticoid is present in the granulosa pathway column and comes from Progesterone by activity of 21 and is metabolized to corticosterone by 11.

in 21 def this compound is not produced so less mineralocorticoid activity and so hyponatremia and hyperkalemia and hypotension (typical presentation in adrenogenital syndrome babies) and reactive increase in the renin and ATII secretion

while in 11 def this compound will accumilate so excessive mineralocorticoid so hypertension and the reactive decrease in renin and ATII
Reply With Quote Quick reply to this message
The above post was thanked by:
Laurentiu (11-28-2009), Pav100 (05-13-2010), wahaha007 (01-10-2010)

Old 04-21-2011
USMLE Forums Scout
Steps History: Not yet
Posts: 26
Threads: 4
Thanked 3 Times in 3 Posts
Reputation: 13

here comes 11 - DOC
Reply With Quote Quick reply to this message


Endocrine-, Physiology-

Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
Beta Hemolytic Microorganisms lee-usmle USMLE Step 1 Buzzwords 1 09-18-2011 11:18 AM
Beta Lactams Resistant To Beta Lactamases! anila USMLE Step 1 Mnemonics 0 12-17-2010 10:38 PM
Variability in biotransformation by liver hydroxylase lemontea88 USMLE Step 1 Forum 2 01-30-2010 09:42 AM
Beta One Selective Beta Blockers rasheed USMLE Step 1 Mnemonics 3 11-26-2009 09:12 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2016 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)