Quick Summary of Nephrotic Syndrome - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum > USMLE Step 1 High Yield > USMLE Step 1 Bits & Pieces

USMLE Step 1 Bits & Pieces High yield short focused points, monographs, charts, illustrations, tables, and other stuff related to the USMLE Step 1 Exam.


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 04-21-2012
Hope2Pass's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,684
Threads: 213
Thanked 1,600 Times in 660 Posts
Reputation: 1610
Kidney Quick Summary of Nephrotic Syndrome

NephrOtic Syndromes:

1) Minimal Change Disease -
  • Seen In: Children
  • Associations: Non Hodgkin's Lymphoma
  • Pathogenesis: Cytokine release
  • H&E: No change, NORMAL Glomeruli
  • EM: Effacement of foot podocytes
  • IF: No change since no Immune complex deposition
  • Good prognosis
  • Tx: Steroids

2) Focal Segmental GlomeruloSclerosis -
  • Seen in: Hispanics & African-Americans
  • Associations: HIV, Heroine User, Sickle cell Disease
  • H&E: Focal & Segmental Sclerosis
  • EM: Effacement of Podocytes
  • Poor Prognosis; Progresses to CRF

3) Membranous GlomeruloNephritis -
  • Seen in: Caucasians
  • Associations: SLE, Hep B, Hep C, Drugs, Tumors
  • Pathogenesis: Immune complex deposition in the SubEPIthelia
  • IF: Granular
  • H&E: Thick GBM
  • EM: SubEPIthelial deposits with "spike-dome" appearance

4) MembranoProliferative Glomerulonephritis -
  • Pathogenesis: Immune complex deposition (Intramembranous & SubENDOthelial)
  • Type 1: SubENDOthelial IC Deposition, increased tram-track appearance, Assc with Hep B or C
  • Type 2: Intramembranous IC Deposition, Pts have C3 nephritic autoantibody which stabilizes C3 Converatse, leading to overactive Complement which causes Inflammation & damage, more often leads to NephrItic syndrome
  • H&E: Thick GBM
  • EM: Tram-track appearance (more prominent in Type 1)

5) Diabetic Nephropathy
  • Pathogenesis: Hyperglycemia leads to Non-Enzymatic Glycosylation of the vascular basement membrane leading to increased permeability ---> Leads to deposits in the Efferent arteriole blood vessel causing narrowing of the lumen ---> Increased back pressure results in Increased filteration
  • Initially results in Microalbuminuria
  • Later on progresses to Sclerosis of the Glomerulus
  • Tx: ACE Inhibitors delay the course (no Angiotensi II = less vasoconstriction of Efferent arteriole)

6) Systemic Amyloidosis
  • Amyloid deposits in mesangium
  • Apple green birefringence under polarized light


Feel free to add to the list in case I missed something!
--------------------------------------------------------------------------------------------------------------------------------

*** Good for practice: Go through these and try to write them down again. Use a simple format like the one I used. EM, IF, H&E, Associations if any, Commonly seen in, Tx if any, etc etc. I was able to write all of this down from memory and it was really good practice! ***
Reply With Quote Quick reply to this message
The above post was thanked by:
aungawa (04-27-2012), didotinu (04-22-2012), docusmle9 (04-22-2012), erickven (05-28-2016), Mondoshawan (04-22-2012), OlgaW007 (03-19-2013), Valkoff (04-21-2012)



  #2  
Old 04-21-2012
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 791
Threads: 76
Thanked 673 Times in 317 Posts
Reputation: 691
Default

First thanks for posting such important topic here and i really appreciate your effort..
There are two corrections- 1)Minimal change disease- the secondary cause or association is HODHKIN'S lymphoma
2) IN type 1 MPGN- deposists are subENDOthelial...I crossed checked these in GOLJAN RR.........
Reply With Quote Quick reply to this message
The above post was thanked by:
didotinu (04-22-2012), Hope2Pass (04-21-2012), Mondoshawan (04-22-2012)
  #3  
Old 04-21-2012
Hope2Pass's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,684
Threads: 213
Thanked 1,600 Times in 660 Posts
Reputation: 1610
Default

Quote:
Originally Posted by anomali View Post
First thanks for posting such important topic here and i really appreciate your effort..
There are two corrections- 1)Minimal change disease- the secondary cause or association is HODHKIN'S lymphoma
2) IN type 1 MPGN- deposists are subENDOthelial...I crossed checked these in GOLJAN RR.........
Thanks for correcting me! You are right with both of those. Unfortunately, I can't edit them out anymore!

Last edited by Hope2Pass; 04-21-2012 at 09:57 PM.
Reply With Quote Quick reply to this message
The above post was thanked by:
anomali (04-21-2012), drglo (11-02-2013)
 
  #4  
Old 04-22-2012
USMLE Forums Scout
 
Steps History: Not yet
Posts: 54
Threads: 12
Thanked 8 Times in 6 Posts
Reputation: 18
Default nephrotic syndr.

Guys, thanks for the topic. Im doing review on renal and i find this point: what is the MCC of nephrotic syndr in adult? FA and Goljan say membranous GLNephritis (M-GLN) but the online Kaplan Qbank says now the focal segmental nephrosclerosis surpasses M-GLN. Which one is correct?
Reply With Quote Quick reply to this message
  #5  
Old 04-22-2012
USMLE Forums Scout
 
Steps History: Not yet
Posts: 54
Threads: 12
Thanked 8 Times in 6 Posts
Reputation: 18
Default

Where do you find the information about focal segmental nephrosclerosis is associated with sickle cell dz? i dont find it in FA and goljan neither. Thanks
Reply With Quote Quick reply to this message
  #6  
Old 04-22-2012
Hope2Pass's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,684
Threads: 213
Thanked 1,600 Times in 660 Posts
Reputation: 1610
Default

Quote:
Originally Posted by sol1411 View Post
Where do you find the information about focal segmental nephrosclerosis is associated with sickle cell dz? i dont find it in FA and goljan neither. Thanks
Learned it in Pathoma.
Reply With Quote Quick reply to this message
The above post was thanked by:
sol1411 (04-22-2012)
  #7  
Old 04-22-2012
USMLE Forums Newbie
 
Steps History: 1 + CK
Posts: 2
Threads: 1
Thanked 1 Time in 1 Post
Reputation: 11
Default

Quote:
Originally Posted by sol1411 View Post
Guys, thanks for the topic. Im doing review on renal and i find this point: what is the MCC of nephrotic syndr in adult? FA and Goljan say membranous GLNephritis (M-GLN) but the online Kaplan Qbank says now the focal segmental nephrosclerosis surpasses M-GLN. Which one is correct?
According to Kaplan Qbank & FA2012, the MCC of nephrotic syndrome in adults is Focal Segmental Nephrosclerosis
Reply With Quote Quick reply to this message
The above post was thanked by:
sol1411 (04-22-2012)
  #8  
Old 04-22-2012
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 3,263
Threads: 147
Thanked 5,053 Times in 1,567 Posts
Reputation: 5149
Default

Quote:
Originally Posted by Hope2Pass View Post
Thanks for correcting me! You are right with both of those. Unfortunately, I can't edit them out anymore!
I edited it for you

-
Reply With Quote Quick reply to this message
The above post was thanked by:
Hope2Pass (04-22-2012)
  #9  
Old 04-22-2012
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 3,263
Threads: 147
Thanked 5,053 Times in 1,567 Posts
Reputation: 5149
Default

Regarding the most common cause of nephrotic syndrome please read here
Most common cause of nephrotic syndrome in adults?

Please discuss this issue further in that thread.

-
Reply With Quote Quick reply to this message
The above post was thanked by:
CHAKRAM (04-27-2012)



Reply

Tags
Pathology-, Renal-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Quick Summary of Nephritic Syndromes Hope2Pass USMLE Step 1 Bits & Pieces 0 04-21-2012 08:20 PM
The cause of Hyperlipidemia in Nephrotic syndrome Evergreen USMLE Step 1 Forum 10 01-17-2012 04:01 PM
the most common nephrotic syndrome in adults chienpolska USMLE Step 1 Forum 1 09-11-2011 06:53 AM
Can Nephrotic Syndrome be infectious? BDP1999 General Topics Forum 2 03-30-2011 05:53 PM
Nephrotic Syndrome Pathogenesis sam01 USMLE Step 1 Forum 2 04-09-2010 02:28 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)