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  #1  
Old 08-06-2016
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Default Drug distribution and redistribution

Distribution

After entering the blood stream, drug moves along the concentration gradient which is in the direction of plasma to tissues, until an equilibrium is established.

Apparent volume of distribution (V): “the volume that would accommodate all the drug in the body, if the concentration throughout was the same as in plasma.”

V = dose administered (IV) / plasma concentration

Redistribution

Highly lipid soluble drugs get initially distributed to organs with high blood flows
These organs include: brain, heart, kidney
Later, organs with low blood flow take up the drug, thus decreasing its plasma concentration.
Drug from the highly perfused organs moves out.

Read more at www.medzepam.com
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Old 08-06-2016
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Default Post link ---

http://medzepam.com/briefly-distribu...edistribution/

Quote:
Originally Posted by jrdrmotwani View Post
Distribution

After entering the blood stream, drug moves along the concentration gradient which is in the direction of plasma to tissues, until an equilibrium is established.

Apparent volume of distribution (V): “the volume that would accommodate all the drug in the body, if the concentration throughout was the same as in plasma.”

V = dose administered (IV) / plasma concentration

Redistribution

Highly lipid soluble drugs get initially distributed to organs with high blood flows
These organs include: brain, heart, kidney
Later, organs with low blood flow take up the drug, thus decreasing its plasma concentration.
Drug from the highly perfused organs moves out.

Read more at www.medzepam.com
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  #3  
Old 08-08-2016
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Default thank you

thank you so much for sharing
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