Hermaphroditism - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum > USMLE Step 1 High Yield > USMLE Step 1 Bits & Pieces

USMLE Step 1 Bits & Pieces High yield short focused points, monographs, charts, illustrations, tables, and other stuff related to the USMLE Step 1 Exam.


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 08-26-2009
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 742
Threads: 137
Thanked 2,462 Times in 441 Posts
Reputation: 2565
Arrow Hermaphroditism

Hermaphrodites are commonly seen in USMLE questions as they are a good example of pathology physiology clinical integration

Here's a short synopsis

Most importantly to remember
the default sex (when no hormones are secreted) is female.

During development if the following is secreted;
  1. Leydig cells ----- testosterone ----- internal male develop
  2. 5 alfa reductase action on testosterone -----dihydrotestosterone ---- external male develop
  3. Sertoli cells ------ Mullerian inhibitory factor ----- internal female prevented

Therefore;
If you don't have a testis such as in testicular dysgensis (for example Klinefilter) you don't have 1 so internal female by default and you also don't have 3 further favoring internal female. Of course if no 1 then no 2 which means no external male.

If you have 5 alfa reductase deficiency then 1 is there so internal male and 3 is there so no internal female but 2 is absent so no external male. They develop penis at 12 year old when more testosterone produced toward puberty.

Androgen insensitivity you have no androgen working on the cells so end up with the default sex (female) what's called testicular feminization syndrome.
Reply With Quote Quick reply to this message
The above post was thanked by:
aungawa (01-14-2013), chenapassi (08-30-2011), devareddy (01-18-2014), drortho (11-28-2011), hassanahk (06-07-2011), K06100 (08-07-2011), pradeeprox (07-17-2012), prep4usmle2012 (08-07-2011), seemaCMC (08-10-2011), shyangel18 (10-14-2011), sweety (08-07-2011), Taiwan_Guy (08-11-2011), wahaha007 (01-10-2010)



  #2  
Old 08-07-2011
USMLE Forums Scout
 
Steps History: 1+CK+CS
Posts: 69
Threads: 4
Thanked 76 Times in 21 Posts
Default

patients with androgen insensitivity do not have normal internal female structures. They have testes and testes produce mullerian inhibitory factor, thus no female internal structures.
Reply With Quote Quick reply to this message
The above post was thanked by:
akua (08-07-2011), bowman (12-13-2012), devareddy (01-18-2014), drortho (11-28-2011), skido (08-07-2011)
  #3  
Old 08-07-2011
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 3,316
Threads: 170
Thanked 4,922 Times in 1,809 Posts
Reputation: 4975
Default

Quote:
Originally Posted by patient doctor View Post
patients with androgen insensitivity do not have normal internal female structures. They have testes and testes produce mullerian inhibitory factor, thus no female internal structures.
Thank you for the correction!

-
Reply With Quote Quick reply to this message
 
  #4  
Old 08-07-2011
USMLE Forums Scout
 
Steps History: Not yet
Posts: 23
Threads: 0
Thanked 5 Times in 5 Posts
Reputation: 15
Default

Still on TFS, they do not have pubic hair which is a function of testosterone which act on receptors in the hair follicles. They develop normal female breast because there is a lost of the inhibitory function of testosterone.
It defers from mullerian agenesis in that, In mullerian agenesis, there is also no development of female internal organs but there is the development of secondary sexual characteristics like breast, Pubic hair because the ovaries are functional, ie not part of the mullerian duct.
Reply With Quote Quick reply to this message



Reply

Tags
Embryology-, Physiology-, Reproductive-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)