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USMLE Step 1 Bits & Pieces High yield short focused points, monographs, charts, illustrations, tables, and other stuff related to the USMLE Step 1 Exam.

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Old 07-27-2012
Dr.Lacune's Avatar
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Wink Amyotrophic lateral sclerosis

Hello Guys,

I came across this classification of ALS, and I thought of sharing it.

Diagnostic criteria: 4 distinct body regions
  • Bulbar - Muscles of the face, mouth, and throat
  • Cervical - Muscles of the back of the head and the neck, shoulders, and upper back, and the upper extremities
  • Thoracic - Muscles of the chest and abdomen and the middle portion of the spinal muscles
  • Lumbosacral - Muscles of the lower back, groin, and lower extremities

  • Clinically Definite ALS: UMN and LMN signs in at least 3 body segments
  • Clinically Probable ALS: UMN and LMN signs in at least 2 body segments with some UMN signs in a segment above the LMN signs

10-20 % is due to superoxide dismutase 1 gene defect. Autosomal dominant .
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Old 06-18-2016
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Default Quick question

Is this needed for step 1 or 2/3?

I just wrapped up neuroscience from FA and don't remember it going into this much details.
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