List of Oncogenic Translocations - USMLE Forums
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  #1  
Old 04-11-2013
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DNA List of Oncogenic Translocations

OK,

This is really confusing and difficult to remember.

Let me list them here;

Follicular Lymphoma:
Chromosome 14 (Ig heavy chain) and Chromosome 18 (bcl-2 inhibit apoptosis)

Burkitts Lymphoma:
Chromosome 14 (Ig heavy chain) and Chromosome 8 (C-myc oncogene)

Mantle Cell Lymphoma:
Chromosome 14 (Ig heavy chain) and Chromosome 11 (bcl-1, Cyclin D)

AML:
Chromosome 15 (PML Gene) and Chromosome 17 (PAR-alpha)

CML:
Chromosome 9 (c-abl oncogene) and Chromosome 22 (bcr, breakpoint cluster region), this is also known as Philadelphia Chromosome

Ewing Sarcoma:
Chromosome 11 and Chromosome 22 (EWS-FLI1)

Please let me know if this is correct and if you want to add more oncogenic translocations
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  #2  
Old 04-26-2013
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ALL:
t(8:14) and t(12:21)
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Old 08-27-2013
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  • MALTOMA: t(14, 1) and t(11, 18)
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Old 08-27-2013
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Acute Promyelocitic Leukemia t (15,17) PML -RARα.

I think that the to most important are CML t(9,22) and APL t(15,17);
Had 3 questions in my step 1 and step 2 ck about that.
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Old 08-27-2013
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ah and I would definetely remember Folicular Lymphoma t(14,18) results in the overexpression of the bcl-2 due to immunoglobulin heavy chain gene (IGH) promoter region.
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