Disseminated Intravascular Coagulation (DIC) HY Concepts - USMLE Forums
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Old 04-19-2011
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Blood Disseminated Intravascular Coagulation (DIC) HY Concepts

Here is a helpful flowchart on the very HY topic of Disseminated Intravascular Coagulation. The image was taken from the kaplan videos but is extremely helpful for memorizing key concepts.

Disseminated Intravascular Coagulation (DIC) HY Concepts-dic.jpg
click image to enlarge

A quick summary of DIC:

Remember its always secondary to another disorder so its treatment is to treat the underlying condition first.

  • Gram negative Sepsis
  • Placental tissue factor activating clotting during Pregnancy
  • Meningococcus and Ricketssia since damange to endothelial cells
  • Acute Mylogenous Leukia M3 type - promeylocytes activate clotting
  • Adenocarcinomas releasign mucin which substitues as tissue factor once it is intravascular.

  • Decreased Platelet Count
  • Prolonged PT and PTT
  • Decreased Fibrinogen
  • Elevated fibrin split products (FDP - D dimers) - this is diagnostic of DIC
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Old 04-19-2011
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DIC can cause Diffuse Cortical Necrosis in kidney with sparing of the medulla.

Just learned that, thought I'd share
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Figures-, Hematology-, Pathology-

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