How is fever produced in the body and the difference between PGI2 and PGE2 - USMLE Forums
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Old 05-19-2011
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Smile How is fever produced in the body and the difference between PGI2 and PGE2

Well, I was sick yesterday so I decided to read up on fever and thought I'd share the pathogenesis.
Inflammatory cells release IL-1/TNF-alpha --> This induces release of IL-6 --> High levels of IL-6 stimulate synthesis/release of Prostaglandin E2 in the Anterior Hypothalamus --> PGE2 increases the temperature setpoint (which is controlled by the anterior hypothalamus) --> Increase in body temperature
Release of PGE2 peripherally is also thought to play a role in the muscle and joint pains associated with fever (one of the functions of PGE2 is pain stimulation)
And for those of us (like me) who always get confused between PGI2 and PGE2, here's a quick comparison: (see page 391 in FA 2011 for reference)


1) Both synthesized by COX
2) Both cause vasodilation (decrease vascular tone)

Unique Functions:


1) Maintains PDA
2) Stimulates Pain
3) Increases temperature set point
4) Increases Uterine Tone


1) Inhibits Platelet aggregation
2) Decreases Uterine Tone

As always, please add anything I missed or point out any errors!
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Old 05-22-2011
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This is a wonderful post.
Thank you very much for sharing and helping
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Biochemistry-, Pathology-, Physiology-

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