Eczema + Petichiae + Immunodeficiency - USMLE Forums
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USMLE Step 1 Classic Clues Classic clues seen in clinical case scenarios in USMLE Step 1 questions.


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  #1  
Old 02-11-2010
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Immunology Eczema + Petichiae + Immunodeficiency

The triad should unmistakeably makes us think of Wiskott-Aldrich syndrome. The USMLE may present for you a male child (because it's X linked recessive) with a very characteristic combination of eczema and petichiae (because of thromobocytopenia).
Platelets are characterisitcally small with low mean platelet volume and there's immunodeficiency characterized by low IgM and high IgA and IgE levels.
Propensity to develop autoimmune disorders and lymphoma/leukemia is there.
keep this syndrome in your mind for the USMLE Step 1 and also for CK.
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Old 08-16-2010
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Default be carefull!!! dont forget to check COLD ABCESSES

JOB'S syndrome has a similar presentation too Eczema + Petichiae + Immunodeficieny but it has COLD ABCESSES.... USMLE may confuse u with it...

It is characterized by recurrent "cold" staphylococcal infections, unusual eczema-like skin rashes, severe lung infections that result in pneumatoceles (balloon-like lesions that may be filled with air or pus or scar tissue) and very high concentrations of the serum antibody IgE. Inheritance can be autosomal dominant, or recessive, and autosomal dominant form of the disease; these patients have problems with their bones including recurrent fractures and scoliosis. Many patients with autosomal dominant hyper IgE syndrome fail to lose their primary teeth and have two sets of teeth simultaneously.
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Old 08-26-2010
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Great! This post is awesome!
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Old 08-27-2010
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Default Wiskott-Aldrich syndrome

hmm Guys lets try it this way.........

Wiskott-Aldrich syndrome Mnemonic
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Old 10-24-2011
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Default of Wiskott-Aldrich syndrome.

mnemonic.... we can remember it as "TIE"
T-thromobocytopenia
I-infections
E-ecema{itching}....
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Old 11-02-2011
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Default

Wiskott Aldrich has a nice TIE, thats how I remember it!
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Immunology-, Skin-, Syndromes-Acronyms

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