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Old 07-27-2014
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Default A 20-year-old woman of Mediterranean descent

An otherwise healthy 20-year-old woman of Mediterranean descent is given sulfamethoxazole to treat a bladder infection. Three days after beginning the antibiotic regimen, the patient has moderately severe jaundice and dark urine. Pain with urination and a low-grade fever have resolved. Her hematocrit is 20%. Substantial numbers of erythrocytes contain Heinz bodies. Her condition worsens until day 6 of antibiotic therapy, when it begins to resolve. Symptoms are completely gone by day 9 of continued antibiotic therapy.
Which of the following conditions is the most likely explanation for these findings?

(A) Aplastic anemia
(B) Generalized cytochrome-b5 reductase deficiency
(C) Glucose-6-phosphate dehydrogenase deficiency
(D) Pyruvate kinase deficiency
(E) Systemic infection cured by antibiotic therapy
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Old 07-27-2014
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c g6pd def. - patients with this deficiency, who take sulfonamides, will experience episodes of hemolytic anemia, due to the increased oxidative stress placed on the RBCs
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