Why triphasic response after cutting the pituitary stalk! - USMLE Forums
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Old 06-06-2011
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Neuro Why triphasic response after cutting the pituitary stalk!

Sectioning of pituitary stalk produces triphasic response
diabetes insipidus ----->SIADH----->DI

Can someone explain why this sequence...or we have to just remember it that way for STEP1?
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Old 06-06-2011
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If you damage the Pituitary stalk One of the first things that goes is ADH bc it is made in the supraopitic paraventricular nucleus of the hypothalamus, it goes down the stalk and is stored in the POSTERIOR pituitary.

So, if you damage that stalk, leads to ADH def. Also def in all the releasing factors that are made in the hypothalamus that stimulate the pituitary, leading to hypopituitarism

Of course, patient eventually will develop sign and sympton of DI = polyurea, thirst, etc etc.
pretty much say it in that way also..
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Old 06-07-2011
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Initially there is shock so no ADH release causing DI then neurohypophyseal cells die releasing stored ADH causing SIADH then finally permanent DI
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Endocrine-, Nervous-System-, Physiology-

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