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Old 08-04-2014
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Help Insulin And cAMP

Here's what I have summarized. Please correct me if its wrong and complete the steps. Thanks a lot.

GDP is inactivated And GTP is activated form. In case of Gi, GTP is an inhibitor of Adenylate cyclase. (Vs GTP in Gs is a stimulator of adenylate cyclase)

Pertusses inhibits GDP to GTP by ADP ribosylation of G protein.

Therefore, We say it inhibits the inhibitor( I.e, GTP ) --> Prevent inhibition of Adenylate --> Inc cAMP.

Now, Why do we have Inc in insulin with Pertusses toxin?

This is what I knew,

Glucose enters b cell of pancreas ---> Metabolism ---> Inc ATP/ ADP ratio----> Closes ATP sensitive potassium channels --->Depolarization ---> Voltage sensitive Ca opens--> Inc intracellular Ca ---> Insulin Exocytosis.

Whats the role of cAMP?

I found this picture,

I am not able to understand the cAMP part here.

Inc cAMP ---> Activate Protien kinase A---> ???? Inc Ca (How?)---> Exocytosis of insulin.(Please any one fill in the gap if possible)

Thanks a lot
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