If the thymus atrophy then how do we get T cell development in adulthood! - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 06-11-2011
USMLE Forums Guru
 
Steps History: ---
Posts: 332
Threads: 48
Thanked 170 Times in 109 Posts
Question If the thymus atrophy then how do we get T cell development in adulthood!

Thymus is crucial for T cell maturation and selection. But it undergoes atropy after childhood, so where do T cell mature after this happens ?

Bebix and others, if you see this, can you help?

Thanks!
Reply With Quote Quick reply to this message
The above post was thanked by:
m82_ghasemi (06-11-2011), struggle (06-11-2011)



  #2  
Old 06-11-2011
bebix's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,357
Threads: 194
Thanked 3,261 Times in 881 Posts
Reputation: 3271
Embarrassed

This is what I found...

The normal thymus largely degenerates into fatty tissue in elderly adults, although it continues to serve as the site of T-cell differentiation and maturation throughout adulthood (ref: "The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals")

So, the bottom line is that even if we are 90y/o, we still have a tiny piece of cortex/medulla working (check the following chart):

If the thymus atrophy then how do we get T cell development in adulthood!-thymus.jpg
click image to enlarge
Reply With Quote Quick reply to this message
The above post was thanked by:
drnirajmavani (06-16-2011), Kashif habib (06-17-2011), m82_ghasemi (06-11-2011), skido (06-16-2011), struggle (06-11-2011), theunique (06-16-2011), usluipek (06-11-2011)
  #3  
Old 06-11-2011
USMLE Forums Guru
 
Steps History: ---
Posts: 332
Threads: 48
Thanked 170 Times in 109 Posts
Default

Thanks, so much bebix!!! That is a magic diagram...............
May be this partially explains why the immune system in elderly is weaker than that of young people.
Reply With Quote Quick reply to this message
The above post was thanked by:
bebix (06-11-2011)



Reply

Tags
Immunology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Claudication + Impotance + Leg atrophy mary USMLE Step 2 CK Classic Clues 1 07-09-2016 12:01 PM
When T Lymphocytes enter the thymus, do they have TCR? struggle USMLE Step 1 Forum 2 05-22-2011 11:45 AM
Thymus associations? hippocampus USMLE Step 1 Forum 3 12-13-2010 07:11 PM
Optic Atrophy Father? ecgram USMLE Step 1 Forum 6 07-15-2010 04:21 PM
Physiology of Disuse Muscular Atrophy Seetal USMLE Step 1 Forum 6 04-24-2010 07:38 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)