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Old 06-11-2011
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Immunology Recurrent Neisseria; C5 or C6?

i got a question with recurrent neisseria infections and in the options were both C5 and C6 seperately.
did not knw which to pick since both in MAC. but ended up picking C5.

wat do u guys think?
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Old 06-11-2011
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Question

could you post the question?

C6 def. is more common than C5 def. though...

check this link

http://books.google.com/books?id=vSP...ciency&f=false
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Old 06-11-2011
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C5a is also a key component of neutrophil chemotaxis, so I would imagine a deficiency of C5 would have a slightly wider range of infectious susceptibility than C6-C9
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Old 06-11-2011
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Post C5-C9 defeciency causes recurrent infection with Neisseria

C5-C9 deficiency all could cause recurrent infection with Neisseria bacteremia. There might be other clues to help select the right answer, for instance:

Patients with C5 deficiency may suffer from Leiner's disease. Patients with Leiner's disease have the symptoms originally described by Leiner, but frequently suffer from repeated infections, mainly with gram-negative bacteria. Symptoms include severe seborrheic dermatitis, severe diarrhea, recurrent local and systemic infection, central nervous system problems, and failure to thrive.

In addition to recurrent infection with Neisseria, patients with C6 deficiency may suffer from chronic brucellosis and toxoplasmosis.

Ref:
http://www.sciencedirect.com.proxy3....90962283701957

http://en.wikipedia.org/wiki/Leiner%27s_disease

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Old 06-11-2011
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Quote:
Originally Posted by susanbal View Post
i got a question with recurrent neisseria infections and in the options were both C5 and C6 seperately.
did not knw which to pick since both in MAC. but ended up picking C5.

wat do u guys think?

Would you PLZ send the question?
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Old 06-12-2011
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dont hv the ques it was on my exam!
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