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Old 06-11-2011
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Question Immunology Question (IL-2 or Aldesleukin)

58-year-old man comes to the physician because of blood in his urine. He had a nephrectomy 10 years ago because of injuries sustained in a motor vehicle collision. Evaluation shows renal cell carcinoma in his remaining kidney and pulmonary metastases. Interleukin-2 (IL-2) therapy is started. Three weeks later, CT scan confirms regression of the tumor. Which of the following most likely caused the regression?

A) An effect of IL-2 on tumor vascularization

B) Cytotoxic effects of IL-2 on tumor cells
C) Increased natural killer cell activity
D) Induction of antitumor antibodies by IL-2
E) Induction of B-lymphocyte proliferation
F) Spontaneous remission
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The above post was thanked by:
apx85 (06-11-2011), Eagle95 (03-24-2015), rulz (06-16-2011), usluipek (06-11-2011)



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Old 06-11-2011
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I think is NK activity...
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Old 06-11-2011
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Answer C:

IL 2 induces proliferation of NK
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Old 06-11-2011
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Thumbs Up Interleukin-2 in the treatment of renal cancer

The mechanism of antitumor efficacy of IL-2 is closely related to its ability to expand and activate cytotoxic lymphocytes of the natural killer (NK)- and thymic (T)-cell subsets that express IL-2 receptors (IL-2R).

http://www.ncbi.nlm.nih.gov/pubmed/10768598

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