Achondroplasia; Large head or not! - USMLE Forums
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  #1  
Old 06-17-2011
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Bones Achondroplasia; Large head or not!

I was going through the musculoskeletal section of FA and stumbled upon achondroplasia, it says that head-size is normal because membranous ossification is not affected....but in UW there is a question and also in the explanation it says that the size of the head is large and also a prominent forehead....

Please could someone explain.
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Old 06-17-2011
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Default Both are correct!

They are both right!

In achondroplasia you have the long tubular bones affected only. As a result, you have short stature/dwarfism and as result the head will look disproportionately larger (compared to the body) but the actual head circumference is not increased.
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Old 06-17-2011
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well at first I also thought that but when they said prominent forehead....maybe he also has acromegaly who knows...
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Old 06-17-2011
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large head compared to rest of body
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Originally Posted by Mashee View Post
well at first I also thought that but when they said prominent forehead....maybe he also has acromegaly who knows...
Prominent forehead does not necessarily mean large head.
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Old 06-17-2011
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no it doesnt...but if he has a prominent forehead doesnt it mean that there is some problem with membranous ossification? i knw it can't be due to the dwarfism but lets just say hypothetically it cud be due to exessive growth hormone????...or maybe they just sd that in the question to trick us..oh and i didn't ask if he has a large head or not... the forum staff changed the title....

or maybe im just freaking out cuz my exam is only about a month away
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Old 06-17-2011
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I guess im being picky...it was a genetics question and i got it ryt anyway....
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Originally Posted by Mashee View Post
no it doesnt...but if he has a prominent forehead doesnt it mean that there is some problem with membranous ossification? i knw it can't be due to the dwarfism but lets just say hypothetically it cud be due to exessive growth hormone????...or maybe they just sd that in the question to trick us..oh and i didn't ask if he has a large head or not... the forum staff changed the title....

or maybe im just freaking out cuz my exam is only about a month away
Did the staff change the content of your post! because it's pretty obvious you are asking whether the head is large or not in achondroplasia.
Anyway, back to the prominent forehead part, yes, I agree with you it can be due to membranous bone defect but it also can be due to anything else, remember this is a genetic defect of Fibroblast growth factor and lots of stuff can be affected.
Also, the UW poeple is wrong about this. The prominent forehead is also relative, it's the midfacial hypoplasia that makes the forehead looks prominent focus on the child face in this pic

Achondroplasia; Large head or not!-achondroplasia-1.jpg
click image to enlarge
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Old 06-17-2011
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Smile Thank you

Thank u for clearing that up now it makes much more sense.....no they didnt change my post lol....and no meanness towards the staff intended i blv they are doing a great job in making this forum it really helped me throughout my prep. Thank you staff

oh and good luck
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Clinical-Signs, Genetics-, Musculoskeletal-, Pathology-, Syndromes-Acronyms

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