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Old 06-17-2011
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Question Patient with Autoimmune disease

A 36 year old female presents with complaints of weakness and shortness of breath on exertion. She says that the dyspnea has progressively worsened over the past few months and now she has noticed that her shoes don't seem to fit right anymore. A chest x-ray shows no signs of pulmonary edema so you think the patient might be suffering from pulmonary hypertension. The patient also reveals that the skin over her fingers has become tight and that her fingers turn blue in the cold weather. Recognizing that this is likley an autoimmune disorder, you order serological tests which come back positive for Anti-ribonucleoprotein antibodies. Which of the following is the most likely diagnosis?

A. SLE
B. Diffuse Scleroderma
C. Mixed Connective Tissue Disease
D. CREST Syndrome
E. Sjogren Syndrome
F. Polymyositis
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Old 06-17-2011
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only anti-RNP (+)???....Mixed Connective Tissue Disease
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Old 06-17-2011
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C. Mixed Connective Tissue Disease
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Old 06-17-2011
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Ufff... Tricky and yes is Mixed connective tissue... If is RNP +!
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Old 06-17-2011
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Quote:
Originally Posted by bebix View Post
only anti-RNP (+)???....Mixed Connective Tissue Disease
In a presentation like this, I feel like we would have to be given the most specific antibody.

Didn't know about this antibody until today so I thought I'd make a question out of it. Apparently everyone knows it already
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Old 06-17-2011
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BTW I made this question, so I apologize if it's not a great question
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Old 06-17-2011
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Quote:
Originally Posted by apx85 View Post
BTW I made this question, so I apologize if it's not a great question
Yeap, i noticed that LOL but yeap still a great question because i got almost something similar on UW...
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Old 06-18-2011
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Quote:
Originally Posted by apx85 View Post
A 36 year old female presents with complaints of weakness and shortness of breath on exertion. She says that the dyspnea has progressively worsened over the past few months and now she has noticed that her shoes don't seem to fit right anymore. A chest x-ray shows no signs of pulmonary edema so you think the patient might be suffering from pulmonary hypertension. The patient also reveals that the skin over her fingers has become tight and that her fingers turn blue in the cold weather. Recognizing that this is likley an autoimmune disorder, you order serological tests which come back positive for Anti-ribonucleoprotein antibodies. Which of the following is the most likely diagnosis?

A. SLE
B. Diffuse Scleroderma
C. Mixed Connective Tissue Disease
D. CREST Syndrome
E. Sjogren Syndrome
F. Polymyositis
c. Mixed connective tissue disease
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