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Old 06-18-2011
dr.muhamad's Avatar
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Question The type of hypersensitivity in Myasthenia Gravis

i found some contradiction between uworld and kaplan (vid)
we know myathenia gravis is type 2 hypersensitivity
but kaplan (vids) says its non-cytotoxic which means no complement activtion same as graves disease...
but in Uworld there is a question about myathenia gravis and in the explanation they say after the Abs bind the Ach receptors it activates the complement and destroy the receptors

so please anyone can give us the sun light here

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Old 06-18-2011
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See the discussion here: Cytotoxic Versus Non-Cytotoxic Type II Hypersensitivity Reaction

Cytotoxic means that the cell is destroyed while non-cytotoxic means that the cell is intact.

Even though in MG ACh receptors are destroyed, the cell is still alive so it is non-cytotoxic

So both are correct. It is non-cytotoxic and the Ab's cause complement mediated destruction of ACh receptors
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dr.muhamad (06-18-2011), viswajeeth (10-02-2016)



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