Magnesium is required for exocytosis of parathyroid hormone - USMLE Forums
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  #1  
Old 06-18-2011
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Thyroid Magnesium is required for exocytosis of parathyroid hormone

hypomagnesemia patients can have hypoparathyroidism and can result in hypocalcemia and hyperphosphatemia ....... i just came to know that the only gland which uses magnesium for exocytosis of its hormone is parathyroid ....
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  #2  
Old 06-19-2011
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Cool. Thanks.
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Old 06-19-2011
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Correct Answer Hmmmm Interesting.

Ive came across that connection before but never knew the underling mechanism of it! now i wont forget it. Thanks for sharing
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Old 06-19-2011
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Now that's something I didn't come across in endocrine physiology...interesting...thanks a lot!
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Old 06-19-2011
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cuz Mg is req for CAMP which is required for PTH to work so yes this is the mechanism!
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Old 06-19-2011
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Stop But...

Quote:
Originally Posted by salz View Post
cuz Mg is req for CAMP which is required for PTH to work so yes this is the mechanism!
There are over a dozen receptors which use cAMP to conduct signals so we'd expect much more than JUST hypoparathyroidism in hypomagnesemia! I agree with the point stated in the thread but you're explanation doesn't fit! could you explain further?!
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Old 06-19-2011
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Quote:
Originally Posted by Drothman2010 View Post
There are over a dozen receptors which use cAMP to conduct signals so we'd expect much more than JUST hypoparathyroidism in hypomagnesemia! I agree with the point stated in the thread but you're explanation doesn't fit! could you explain further?!
What you mean, explain further. Didn't I just do that?
Ill say the same, PTH requires CAMP and CAMP requires adenyl cyclase and adenyl cyclase works in the presence of Mg... so No Mg, means dec PTH...
You don't belive me? Go see goljan, it has to be in endo section under hypoparathyroidism
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Old 06-19-2011
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Quote:
Originally Posted by salz View Post
What you mean, explain further. Didn't I just do that?
Ill say the same, PTH requires CAMP and CAMP requires adenyl cyclase and adenyl cyclase works in the presence of Mg... so No Mg, means dec PTH...
You don't belive me? Go see goljan, it has to be in endo section under hypoparathyroidism
@salz, I think Drothman2010 was asking if this happens to all the receptors that use cAMP to conduct signals.
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Quote:
Originally Posted by bebix View Post
@salz, I think Drothman2010 was asking if this happens to all the receptors that use cAMP to conduct signals.
@ bebix, I hope we are reading the same page, cuz he put a "wrong ans" sign in response to my post and also said, "your explanation doesn't fit here"
that is why i am asking him to read goljan.
And I am sorry bebix I don't know about others!
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Old 06-19-2011
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Arrow I dont question your source but...

Quote:
Originally Posted by bebix View Post
@salz, I think Drothman2010 was asking if this happens to all the receptors that use cAMP to conduct signals.
Thanks for further explaining my point bebix. Allow me to add an example. If cAMP requires Mg++ to work then hypomagnesemia would affect the function of other hormones that require cAMP to trasmit their signal such as CRH, ACTH, TSH, Glucagon and the list goes on. We have established the association between Mg++ and hypoparathyroidism which could be easily explained through the mechanism provided in the starting thread but the explanation you provided salz although may explain that association, fails at explaining the normal function of other hormones that requires cAMP to work. I hope that was not too confusing
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Old 06-19-2011
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oh boy, you really should have this debate with goljan if you get a chance mr dorthman lol
i will be reading it with some snacks! lol
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btw i do agree with what ur saying!
Mg def should affect all other hormones as well!
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  #13  
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Correct Answer Then...

Quote:
Originally Posted by salz View Post
btw i do agree with what ur saying!
Mg def should affect all other hormones as well!
.... you and I should take that with goljan and see what he has to say for himself
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hahahaha! challenged by Mr. drothman...
he will make something up! lol
he can fool me so easily and i will believe him even if he is lying! hahaha
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  #15  
Old 06-19-2011
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@salz u are also right ... dear fellows some of the concepts in goljan contradict to kaplan everyone knows that .. but i think CAMP has linkage with adenylyl cyclase and then causes PHOSPHORYLATION of enzymes and thsu renders enzymes active or deactivate it .. all i want to say was that other hormone requires calcium for exocytosis , and parathyroid in the one which requires magnesium .. .. if anyone has updated knowledge then u can also add it ... just chill dude ............
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