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Old 06-22-2011
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DNA Huntington disease germline expansion!

I am very confused with huntington dz in males vs. females...what does it mean with "germline expansion in females"??? page 88 FA does not occurs in males?? i thought that when it comes from the father, also occurs an please!!! thanks:
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Old 06-22-2011
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Huntingtons disease affect both male & females. Slightly different features occur, depending on whether the abnormal gene is inherited from mother or father. "germline expansion in females"... The disease is due to expansion of a trinucleotide repeat on chromosome 4 & frequently shows anticipation i.e younger age of onset in subsequent generations.
"A ship in the harbor is safe,but that is not what ships were built for."-Donald Kendall.
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Old 06-22-2011
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i think FA is wrong about this im not sure but i blv it is a paternal germline expansion ...
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Genetics-, Syndromes-Acronyms

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