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  #1  
Old 08-31-2014
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Default CF vs Kartagener Syndrome

Good morning everyone ..
Can someone tell me how to differentiate between Kartagener Syndrome from Cystic fibrosis ..I have a question of 25 yrs old man with Bronchiectasis and Infertility due to sperm defective motility and didn't mention anything else ..
and the answer was Kartagener , why It can't be CF ?
Is It the age factor ?
thank you very much
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Old 08-31-2014
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As a board rule by Dr fischer.. they have to give you something to choose specific answer and if it was cystic fibrosis, then they must have had given sweat salt testing etc.. more over presentation of cystic fibrosis is mostly childhood because of recurrent infections.
So Go for kartagener syndrome here because triad( brochioectasis, situs inversus and infertility)is specific for KS than CF.
Hope this helps..and if i am wrong, please correct me.
Thanks
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wa87el (09-01-2014)
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Old 09-01-2014
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Thank you very much
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Old 09-01-2014
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Also remember that Kartagener's syndrome affects cillia motility and in this instance the infertility was a clue that his sperm weren't working properly (due to cilia dysfunction). Kartagener's sufferers have a defect in the dyenein protein which is what gives cilia they're motility. A woman with Kartagener's would also be infertile because the cilia in the fallopian tubes are needed to transport a fertilized egg up to the uterus.
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Old 09-01-2014
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infertility in broncheactasis is due to absent of vas deferens in male. there is nothing to do with sperm motality defect as is in kartneger syndrome.
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