Reninomas

[laithbv]

I've seen a UW question talking about reninomas which I did not read in Kaplan or FA.
Can anybody enlighten me please

[cuteguy]

Dear Laithbv,
I heard about reninomas from kaplan endocrinology videos of 2002 by charles faesilis and he liked to relate them with bartter's syndrome and gitelman's syndrome which affect loop of henle and distal tubules subseqently and are characterized by excessive loss of NaCl which leads to excess renin secretion.

Hope I helped
Good Luck

[Ahmed-USMLE]

You need to understand the RAA axis and you can answer all related questions.
Low volume state --> Renin --> Angiotensin --> Aldosterone

If the beginning of the problem is Aldosterone (primary hyperaldosteronism) then you will have low renin by negative feedback.

If the beginning of the problem is low volume state (secondary hyperaldosteronism) then your renin will be high.

That UW question can easily be answered following the sequence above.

Causes of secondary hyperaldosteronism include:

• Renovascular hypertension - renal artery stenosis
• Low volume states (congested liver in heart failure is an example)
• Reninomas which secrete renin autonomously from the JG apparatus

[tomymajor]

The idea now is :
1) you have increased renin which in turn increase the aldosterone so now you have both increased renin and aldosterone which is called 2ry hyperaldosteronism
2 ) DD :
1ry hyperaldosteronism ( with low renin) :
adrenal adenoma ( conns syndrome ) , hyperplasia , Glucocort icoid mediated
2ry hyperaldosteronism( with high renin):
renin secrating tumour, Renal artery stenosis , Cirrhosis , Hf , CRF , Chronic laxatives use , Hypothyroidism

[memory]

Originally Posted by tomymajor

The idea now is :
1) you have increased renin which in turn increase the aldosterone so now you have both increased renin and aldosterone which is called 2ry hyperaldosteronism
2 ) DD :
1ry hyperaldosteronism ( with low renin) :
adrenal adenoma ( conns syndrome ) , hyperplasia , Glucocort icoid mediated
2ry hyperaldosteronism( with high renin):
renin secrating tumour, Renal artery stenosis , Cirrhosis , Hf , CRF , Chronic laxatives use , Hypothyroidism

glucocorticoid mediated primary hyperaldosteronism? mechanism?

[lee-usmle]

Originally Posted by memory

glucocorticoid mediated primary hyperaldosteronism? mechanism?

This thread may help explain your question
Cushing's Potassium Metabolism?