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Old 09-03-2014
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Default Some more questions

Q.1 A 75 year old goes to phys due to shortness of breath and chronic cough over past 10 years.he has more than 100 pack smoking hx. Pt has barrel chest, often purses his lips when he breathes. He has diminished breath sounds. ABG shows partial arterial pressure of 75 and carbondioxide of 50.
As a result of this disease the substrate of which enzyme has built up in the patients lungs?
A) ACE
B) ATP synthase
C) carbonic anhydrase
D) NADPH oxidase
E) topoisomerase


Q2. A 17 year old girl recently prescribed sulfamthoxole and TMP. for UTI.
pt came back after 3 days with fatigue,dark urine,yellow skin and sclera. Phys suspect G6PD def.
What compound build up in this disease?
A) hb
B) NAD
C)NADPH
D) oxidized glutathione
E) reduced glutathione


Q3. A 5 year old girl to ER with vomiting and diffuse abd pain. Lab shows
Na 130
K 5.2
Cl 94
Hco3: 9
BUN 35
Cr 1.2
Glucose 368 mg/dl
ABG PH 7.20
Histo examination of the organ responsible for her symptoms will reveal which of following?
A) amyloidosis
B) apoptotic bodies
C) lymphocytes
D) monocytes
E) viral inclusion bodies
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Old 09-03-2014
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Q1 - C) carbonic anhydrase

Q2 - D) oxidized glutathione
No NADPH oxidase, which can be used to reduce oxidized glutathione (GSSG). SO, it accumulates in the presence of an oxidative stress.
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Last edited by MananaMD; 09-03-2014 at 03:44 AM.
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Old 09-03-2014
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1. C
2. D
3. Not sure. I know It's type 1 DM with DKA obviously not amyloidosis.
Let me go for lymphocyte, more of T helper cells.
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Last edited by nsesereso; 09-03-2014 at 04:54 AM.
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Well guys nice try for the first two Qs.
So what ll be ur guess for the third one?
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Old 09-03-2014
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Q3 - Lymphocytes?

I agree, that It's DKA, seen in DM type1 - an autoimmune response against beta cells, involving autoreactive CD4+ T helper cells and CD8+ T cells & autoantibody-producing B cells
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Yes its right.
Its DKA and pt with DM1 suffers from this and most imp cause of DM1 is autoimmune insulitis. So on histology slide pancreases reveals reduction of number and size of islets cells plus leukocyte infiltration of islets called insulitis which involves T lymphocytes.
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