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Old 06-28-2011
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Immunology Immune defense against AFB positive fluids!

54 year-old homeless man has a chronic cough, a cavitary lesion of the lung, and is sputum positive for acid-fast bacilli. Which of the following is the principle form of defense by which the patient's body fights this infection?

A. Antibody-mediated phagocytosis
B. Cell-mediated immunity
C. IgA-mediated hypersensitivity
D. IgE-mediated hypersensitivity
E. Neutrophil ingestion of bacteria
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Old 06-28-2011
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B. Cell mediated immunity.
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Old 06-28-2011
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cell-mediated immunity=> formation of granulomas.
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Old 06-28-2011
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yea i go with cell mediated too! unless there is no other tricky point hidden in this Q!
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answer is B
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Old 06-28-2011
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The principle host defense in mycobacterial infections (such as this patient's tuberculosis) is cell-mediated immunity, which causes formation of granulomas. Unfortunately, in tuberculosis and in many other infectious diseases characterized by granuloma formation, the organisms may persist intracellularly for years in the granulomas, only to be a source of activation of the infection up to decades later.
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