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Old 06-29-2011
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Question The concept of Insulin Resistance

hey guys, this may be a dumb question, but why is there insulin resistance in acromegaly, or like fat ppl, etc.....like is there any simple way to think about why ppl get insulin resistance
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Old 06-29-2011
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I believe in those states, you have constant hyperglycemia, which leads to continous insulin secretion, which will soon cause down regulation of insulin receptors.
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Old 06-29-2011
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Quote:
Originally Posted by jattdoc View Post
yea wiki has a very long article...im wondering if anyone else who is comfortable with this topic can help me out...jus a breif explanation..anyone?....

For obese persons,the cause is increase Free fatty acids and triglycerides..by an unclear mechanism..but serine phosphorylation of beta subunit of insulin receptor is known to be involved.Unlike tyrosine kinase phosphorylation,serine phosphorylation interferes with downstream signaling..TNF,glucagon and glucocorticoid is also involved in the resistance mechanism..FFA also decrease insulin release.This is known as Lipotoxicity.So,lowering Free fatty acids improves beta cell function and insulin resistance.
Source..UW
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