The concept of Insulin Resistance - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 06-29-2011
USMLE Forums Scout
Steps History: 1+CK+CS
Posts: 79
Threads: 18
Thanked 118 Times in 28 Posts
Reputation: 128
Question The concept of Insulin Resistance

hey guys, this may be a dumb question, but why is there insulin resistance in acromegaly, or like fat ppl, is there any simple way to think about why ppl get insulin resistance
Reply With Quote Quick reply to this message

Old 06-29-2011
USMLE Forums Master
Steps History: 1+CK+CS+3
Posts: 1,175
Threads: 38
Thanked 854 Times in 478 Posts
Reputation: 864

I believe in those states, you have constant hyperglycemia, which leads to continous insulin secretion, which will soon cause down regulation of insulin receptors.
To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
Reply With Quote Quick reply to this message
The above post was thanked by:
bebix (06-29-2011), struggle (06-29-2011)
Old 06-29-2011
USMLE Forums Guru
Steps History: Not yet
Posts: 324
Threads: 70
Thanked 239 Times in 144 Posts
Reputation: 249

Originally Posted by jattdoc View Post
yea wiki has a very long wondering if anyone else who is comfortable with this topic can help me out...jus a breif explanation..anyone?....

For obese persons,the cause is increase Free fatty acids and an unclear mechanism..but serine phosphorylation of beta subunit of insulin receptor is known to be involved.Unlike tyrosine kinase phosphorylation,serine phosphorylation interferes with downstream signaling..TNF,glucagon and glucocorticoid is also involved in the resistance mechanism..FFA also decrease insulin release.This is known as Lipotoxicity.So,lowering Free fatty acids improves beta cell function and insulin resistance.
Reply With Quote Quick reply to this message


Endocrine-, Physiology-

Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
Visual reflexes concept lemontea88 USMLE Step 1 Forum 5 12-06-2012 01:35 PM
NBME Form 7 Tested concept apx85 USMLE Step 1 Forum 4 06-18-2011 05:06 PM
The concept of Incompetent Patients docoftheworld USMLE Step 2 CK Forum 23 06-04-2011 09:37 AM
A-a gradient concept kemoo USMLE Step 1 Forum 4 04-30-2011 06:51 PM
Glaucoma Concept. donofitaly USMLE Step 1 Forum 1 02-19-2011 03:59 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)