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  #1  
Old 07-02-2011
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Kidney Renal Toxin effect on GFR and arteriolar resistance!

Which of the following changes, compared with normal, would you expect to find 3 weeks after a patient ingested a toxin that caused sustained impairment of proximal tubular NaCl reabsorption? Assume that there has been no change in diet or ingestion of electrolytes.

qs renal.bmp

A) A (same - same - up)
B) B (same - same - down)
C) C
D) D
E) E

Last edited by bebix; 07-02-2011 at 02:11 PM. Reason: thanks mle2resident
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Old 07-02-2011
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A and B options are same...!!
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  #3  
Old 07-02-2011
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Quote:
Originally Posted by mle2resident View Post
A and B options are same...!!
sorry about that....A) should be up and B) down
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Old 07-02-2011
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Then I think B cud be the answer...!!
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Old 07-02-2011
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Default Ans.

I think answer is E, if there is a sustained impairment of NaCl reabsorption angiotensin II levels would increase, constricting efferent arteriole and increasing GFR.
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Old 07-02-2011
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i think C but am not sure , good job Bebix
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Old 07-02-2011
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i believe it is C
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good one...I think the answer is D)
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Correct Answer correct answer

The correct answer is D)

Impairment of proximal tubular NaCl reabsorption would increase NaCl delivery to the macula densa, which in turn would cause a tubuloglomerular feedback-mediated increase in afferent arteriolar (AA) resistance. The increased AA resistance would be a transient increase in sodium excretion, but after 3 weeks, steady-state conditions would be achieved. Sodium excretion would equal sodium intake, and no significant change would occur in urinary sodium excretion.

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after answer is told by bebix...I GO WITH HER-------> ( D )
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