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  #1  
Old 07-05-2011
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Question Man with breast cancer

A 31-year-old man has a unilateral breast lump. A biopsy is performed, and the pathology report, surprisingly, shows an early-stage carcinoma. The manís family history reveals no history of breast cancer.

What would the physician be most likely to advise?


A. Hormone studies
B. Karyotype
C. Prophylactic mastectomy
D. BRCA1 and BRCA2 gene studies for the patientís younger sister
E. IQ test
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  #2  
Old 07-05-2011
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B. karyotyping
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Old 07-05-2011
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Gene studies for the patient younger sister
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Old 07-05-2011
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I will go with D ??
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Old 07-05-2011
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Default Ans.

B. Karyotype. The patient has no familiar breast cancer history. One of the most common causes of Breast cancer in men is Klinefelter syndrome.
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i will go for D..

Last edited by struggle; 07-05-2011 at 08:53 PM. Reason: Didnt read the question carefully..:(
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Old 07-05-2011
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Default D) BRCA association in family members

I would choose D)BRCA1 and BRCA2 gene studies for the patient’s younger sister,

men with breast ca has strong association BRCA1 mutation in the family members ----Goljan
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Old 07-05-2011
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B..karyotyping.. as klinefelter's is known to cause breast ca in men..!!
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klinefelter seems likely here so i m with karyotyping...
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Old 07-06-2011
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i think it is D???
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Correct Answer correct answer

The answer is B. The rarity of breast cancer in men makes the possibility of Klinefelter syndrome (XXY) likely.

Hormone studies (choice A) will not add to the diagnosis (although they may become useful later in his care).
The patientís other breast should be evaluated carefully, although mammography may not be useful at this stage and it is premature to suggest prophylactic mastectomy (choice C).
Unless suggested by the pedigree, studies of the patientís sister (choice D) are not indicated.
An IQ test (choice E) is not indicated unless concerns arise about his mental status.
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  #12  
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I would say B. Karyotype... b/c no history of breast cancer in the family...Klinefelter increases the risk for men in breast cancer..
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  #13  
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Good question.... Had me thinking!!
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  #14  
Old 07-06-2011
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very good question
but i just want to put it in a sentence :you mean klinefelter syn increase the risk of breast cancer to make it more than it is in women??
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Old 07-06-2011
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Quote:
Originally Posted by dr.muhamad View Post
very good question
but i just want to put it in a sentence :you mean klinefelter syn increase the risk of breast cancer to make it more than it is in women??
when did I say that?
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Old 07-06-2011
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not you elizabeth said sth like that
and in the history u said no family history
so this man has increased risk over his sisters?? am i right
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Quote:
Originally Posted by dr.muhamad View Post
not you elizabeth said sth like that
and in the history u said no family history
so this man has increased risk over his sisters?? am i right
Well, if he is 47 XXY and there is NOT history in his family, the risk at his age (31 y/o) is greater than for her sister
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  #18  
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Default d

my answer z prophylactic mastectomy
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