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  #1  
Old 07-06-2011
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Urine Sample Increased renal clearance in Alcohol Binge!

to celebrate end of semester a college student goes to bar and drinks alcohol binge. she drinks day and night for 3 days. during this period her urinary flow rate increased from 1 to 10ml/min.
this increase in flow rate will increase clearance of??

a) inulin
b) penicillin
c) urea
d) phosphate
e) creatinine
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Old 07-06-2011
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aaaaaaaaaaaaaaa
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  #3  
Old 07-06-2011
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Default C

C --> urea
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Old 07-06-2011
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C) urea
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Old 07-06-2011
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i think its urea..
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Old 07-06-2011
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Think I'll go with C. urea on this, not sure.
Think it's urea because it gets filtered and then reabsorbed; the more dilute the filtrate, the less gets reabsorbed, hence increased clearance.

Going by process of elimination:
a & e: I don't think it's inulin or creatinine because those substances are routinely used to measure patients' GFR; if they fluctuated based on how much fluid you drank or how dehydrated you were, they wouldn't be good measures of kidney function.
c & b) not sure about phosphate and penicillin


Can you guys please explain your reasoning why you choose particular answers...

Last edited by heights; 07-06-2011 at 11:32 PM. Reason: Changed from B to C
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Old 07-07-2011
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UREA!!!!!!!!!!!!!!!!!
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Old 07-07-2011
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answer is urea
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Old 07-07-2011
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Quote:
Originally Posted by IKR123 View Post
to celebrate end of semester a college student goes to bar and drinks alcohol binge.she drinks day and night for 3 days.during this period her urinary flow rate increased from 1 to 10ml/min.
this increase in flow rate will increase clearance of??

a)inulin
b)penicillin
c)urea
d)phosphate
e)creatinine
urea xcretion depends on urine flow rate so ans is urea
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Old 07-07-2011
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Correct Answer correct answer

(C) UREA
urine flow rate is controlled by ADH.which regulates amount of pure water retained in urine.ADH also controls reabsorption of urea in collecting duct.
high urine flow rate means low ADH so IT WILl INCREASE UREA EXCRETION (KAPLAN Q BOOK)
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Old 07-07-2011
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Answer is Urea, the reason is that when ADH gets into V2 receptor and basically gets the aquaporins to reabsorb water, and urea is allowed to follow water there. aquaporins are selective and dont let e- or other substances to be reabsorbed, but urea can.

Son when the guys drank his face off, he inhibited V2 receptors to let aquaporins reabsorb water into the collecting duct. By doing so, urea is excreted, and ... increasing its clearence.
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