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  #1  
Old 07-07-2011
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Question Differentiating bone from hepatic metastasis!

66-yr-old man with squamous cell carcinoma of the lung has an increase in serum alkaline phosphatase activity.
Which of the following enzymes will be most useful in differentiating bone & hepatic metastases?
A. Acid phosphatase
B. Aldolase
C. Amylase
D. Gamma-Glutamyltransferase
E. Lactate dehydrogenase
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  #2  
Old 07-07-2011
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D. Gamma-Glutamyltransferase
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Old 07-07-2011
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A or D
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Old 07-07-2011
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a..............
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Old 07-07-2011
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Quote:
Originally Posted by dr.Irina View Post
A or D
Answear D. for sure!
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Old 07-07-2011
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Quote:
Originally Posted by montre View Post
Answear D. for sure!
please give explanation d) is specific for gall bladder??
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Old 07-07-2011
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D is specific for Liver Disease, while ALP is for Bone and liver disease, if Gamma-Glutamyltransferase is normal, then the pathology here is for Bone disease.. Gamma-Glutamyltransferase even increase first than AST or ALT...

So for sure, answer is D

Psst: Same explanation is given under GI section over FA.
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Old 07-07-2011
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Quote:
Originally Posted by rulz View Post
D is specific for Liver Disease, while ALP is for Bone and liver disease, if Gamma-Glutamyltransferase is normal, then the pathology here is for Bone disease.. Gamma-Glutamyltransferase even increase first than AST or ALT...

So for sure, answer is D

Psst: Same explanation is given under GI section over FA.
yes D is the answer , although ALP can also tell us the site of the lesion /

ALP from bone is heat labile ,
while ALP drom liver is Heat stable
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  #9  
Old 07-08-2011
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i m with gGT

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Old 07-08-2011
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Quote:
Originally Posted by montre View Post
66-yr-old man with squamous cell carcinoma of the lung has an increase in serum alkaline phosphatase activity.
Which of the following enzymes will be most useful in differentiating bone & hepatic metastases?
A. Acid phosphatase
B. Aldolase
C. Amylase
D. Gamma-Glutamyltransferase
E. Lactate dehydrogenase
gamma glutamyl transferase present in hepatic metastasis
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  #11  
Old 07-10-2011
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i thnk d is rite answer,
well nice question
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Old 07-18-2011
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Quote:
Originally Posted by qurat21 View Post
gamma glutamyl transferase present in hepatic metastasis
Acid phosphatase is produced also in liver?

What is ALP ? Sorry for my nonunderstanding
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  #13  
Old 07-18-2011
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Quote:
Originally Posted by Chemole View Post
Acid phosphatase is produced also in liver?

What is ALP ? Sorry for my nonunderstanding
Np, Its Alkaline Phosphatase!
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  #14  
Old 06-13-2016
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Most human tissues contain ALP; kidney, liver, bone, intestine, and placenta. the majority of sustained elevated ALP level are associated with disorder of liver or bone or both.
Gamma glutamyl transferase (GGT) is found in renal, prostatic, pancreatic, and hepatobiliary tissues. Hepatobiliary disease is the predominant source of increased serum GGT.
Therefore GGT level help to differentiate between liver and bone disease.
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