Gram Negative non-fermenters rods in Urine! - USMLE Forums
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Old 07-08-2011
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Urine Sample Gram Negative non-fermenters rods in Urine!

A patient with dysuria and urgency and hematuria came to clinic and his urine is sent to lab. the technician isolated gram -ve rods that are non-fermenters
which is causative agent?

a) E.coli
b) pseudomonas
c) mycoplasma
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Old 07-08-2011
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pseudomonas....
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Old 07-08-2011
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non lactose fermenter ---pseudomonas
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Old 07-08-2011
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its pseudomonas....
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Old 07-08-2011
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A. UTI- must be e-coli
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Old 07-08-2011
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Pseudomonas,tab,18.6 lange review of microbiology,
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Old 07-08-2011
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yea i think pseudomonas
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Old 07-09-2011
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P aeruginosa:
opportunistic,
nosocomial: Pneumonia,
osteomyelitis, burn infections,
sepsis, UTI, endocarditis, malignant
otitis externa, corneal infections.
P. cepacia colonizes CF patients
Strict aerobe,
Not glucose
fermenting, Not
reduce nitrates,
oxidase +
Normal flora of colon. Exotox like
C.diptheriae
(ADPreibosylation)
Produces pyocyanin,
pyoverdin
Highly resistant.
Combo pipercillin,
ticarcillin and
aminoglycoside.
Ceftazidime

ecoli
Most common UTI, Gm- sepsis, traveller’s
diarrhea. 2nd most common cause of
Neonatal meningitis.
Enterotoxigenic strains: Do NOT invade!
heat labile enterotox binds GM1 ganglioside
receptor, activates adenylate cyclase via
ADPribosylation of G protein. (like Cholera
tox) Watery diarrhea.
Enterohemorragic: verotoxin inhibits 60s
ribosome (like Shigella) Bloody diarrhea.
0157:H7 type causes hemolytic-uremic
syndrome (anemia, thrombocytopenia, renal
failure) associated w/ fast food outbreaks
Enteroinvasive: factor mediated invasion of
epithelial cells, sepsis. Bloody diarrhea with
WBCs.
As other
enterobacteria
ciae family
Normal flora,
but need
virulence
factors to cause
disease.
Pathogenisis by pilus
and enterotox,
capsule, and
endotoxin.
Serotype ID by O,H,K
antigens
Ferments lactose, unlike
Salmonella, Shigella
G3 Cephalosporin No vaccine

mycoplasma
“Walking pneumonia”
(dry nonproductive cough,
horrible CST, generally
feel well) Most common
pneumonia in young
adults (college students).
Smallest free living
organism, no cell
wall so poor gm
stain, resists
penicillins,
cephalosporins.
Cell membrane has
chol which are not
in other bacteria.
“Fried egg”
colonies on Eaton’s
agar. (“Eat Fried
Eggs w/ chol”)
Respiratory droplets.
Attaches but does NOT
invade respiratory
epithelium, like
B.pertussis.
Pathogenic only for
humans.
Arrests cilliary motion,
induces epithelial cell
necrosis. Cross reactive
antigens induce anti RBC
autoantibodies (cold
agglutinins.)
Elevated titer of cold
agglutinins or specific
anitbodies
Erythromycin
Tetracycline
No vaccine
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