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  #1  
Old 09-25-2014
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Default Renal physiology Question

A study of renal clearance is conducted with a substance which is both freely filtered and maximally secreted . which of the following will most likely happen to the renal clearance of the substance as the plasma concentration of the substance increases ?
a-decreases and approaches that of inulin
b-decreases to zero
c-increases and approaches that of inulin
d-increases to the renal plasma flow
e-remains the same
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  #2  
Old 09-25-2014
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will go with A
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Old 09-25-2014
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Ok will take C
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Last edited by nsesereso; 09-25-2014 at 08:51 AM.
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Old 09-25-2014
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I made mistake. I think answer is A
It functions just like PAH
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Old 09-25-2014
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Default My answer

Ill go with AA too.

Here's my reason:

Initially when everything is filtered and maximally secreted its clearance is equal to renal plasma flow or clearance of PAH.

But when you keep on increasing the concentration, the carriers will get saturated and it won't be able to secrete anymore

The clearance will go on decreasing till the clearance of the substance is only by glomerular filtration. So now clearance will be equal to GFR or clearance of inulin.

That is how clearance decreases and reaches GRF or (inulin clearance).

This is the concept behind Transport max. Thanks for the question.
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Old 09-25-2014
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Ill go with A too...because secretion is an active process gets saturated...
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Old 09-26-2014
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Yes The correct answer is A for the reason mentioned by Drnewb , well done guys
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