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Old 07-13-2011
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Drug anabolic steroid therapy

If we infuse anabolic steroid( androgen) to a man, we can predict that his LH must go down due to feedback inhibition, but how about FSH? FSH is gonna go up or down?

I think FSH is gonna go down because of extenal testosterone, LH goes down; without LH, then sertoli cells are gonna disappeared as well( but i do not know why without LH, sertoli cells cannot survive), without sertoli cells, no more inhibin, so no more back regulation for FSH, then FSH is going up.

But Kaplan says that without LH, then no more sertoli cells( till here I can still accept), then without sertoli cells, FSH is gonna be low. ????

Can someone please explain this? And please also explain why without LH, sertoli cells are gonna disappear.
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Old 07-13-2011
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Originally Posted by chienpolska View Post
I think FSH is gonna go down because of extenal testosterone, LH goes down; without LH, then sertoli cells are gonna disappeared as well( but i do not know why without LH, sertoli cells cannot survive), without sertoli cells, no more inhibin, so no more back regulation for FSH, then FSH is going up.
I believe you think that FSH should be going up? Because you started off saying that it should go down but by the end of it you said FSH should go up! lol

Anyways, I think FSH should go down coz anabolic steroids are basically testosterone! So testosterone would inhibit GnRH secretion from the hypothalamus and that would decrease both LH & FSH. Overall, it will cause hypogonadotrophic hypogonadism leading to decreased levels of LH, FSH & Testosterone (endogenous) ... This leads to atrophy of testes and decreased spermatogenesis. Here is a diagram for reference -
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Old 07-13-2011
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Originally Posted by Hope2Pass View Post
I believe you think that FSH should be going up? Because you started off saying that it should go down but by the end of it you said FSH should go up! lol

Anyways, I think FSH should go down coz anabolic steroids are basically testosterone! So testosterone would inhibit GnRH secretion from the hypothalamus and that would decrease both LH & FSH. Overall, it will cause hypogonadotrophic hypogonadism leading to decreased levels of LH, FSH & Testosterone (endogenous) ... This leads to atrophy of testes and decreased spermatogenesis. Here is a diagram for reference -
So the negative feedback of testosterone on the hypothalamic hormone GnRH is the main thing. The loss of inhibin effect on FSH wud not matter anymore....ryt?
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Old 07-13-2011
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Originally Posted by Hope2Pass View Post
I believe you think that FSH should be going up? Because you started off saying that it should go down but by the end of it you said FSH should go up! lol

Anyways, I think FSH should go down coz anabolic steroids are basically testosterone! So testosterone would inhibit GnRH secretion from the hypothalamus and that would decrease both LH & FSH. Overall, it will cause hypogonadotrophic hypogonadism leading to decreased levels of LH, FSH & Testosterone (endogenous) ... This leads to atrophy of testes and decreased spermatogenesis. Here is a diagram for reference -

Sorry for wrong typing and your sweet understanding what i meant now this explain it.
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So the negative feedback of testosterone on the hypothalamic hormone GnRH is the main thing. The loss of inhibin effect on FSH wud not matter anymore....ryt?
Yeah loss of inhibin effect on FSH does not matter coz you would have low levels of FSH to begin with so it would result in low levels of inhibin.
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