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Old 10-01-2014
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Default CD molecules

Principal Features of Selected CD Molecules
The following list includes selected CD molecules that are referred to in the text. Many cytokines and cytokine receptors have been assigned CD numbers, but we refer to these by the more descriptive cytokine designation. A complete and up-to-date listing of CD molecules may be found at .
CD Number (Other Names) Molecular Structure, Family Main Cellular Expression Known or Proposed Function(s)
CD1a-d 49 kD; class I MHC-like Ig superfamily; β 2-microglobulin associated Thymocytes, dendritic cells (including Langerhans cells) Presentation of non-peptide (lipid and glycolipid) antigens to some T cells
CD1e 28 kD; class I MHC-like; β 2-microglobulin associated Dendritic cells Same as CD1a
CD2 (LFA-2) 50 kD; Ig superfamily T cells, NK cells Adhesion molecule (binds CD58); T cell activation; CTL- and NK cell–mediated lysis
CD3γ 25-28 kD; associated with CD3δ and CD3ε in TCR complex; Ig superfamily; ITAM in cytoplasmic tail T cells Cell surface expression of and signal transduction by the T cell antigen receptor
CD3δ 20 kD; associated with CD3γ and CD3ε in TCR complex; Ig superfamily; ITAM in cytoplasmic tail T cells Cell surface expression of and signal transduction by the T cell antigen receptor
CD3ε 20 kD; associated with CD3δ and CD3γ in TCR complex; Ig superfamily; ITAM in cytoplasmic tail T cells Cell surface expression of and signal transduction by the T cell antigen receptor
CD4 55 kD; Ig superfamily Class II MHC–restricted T cells; some macrophages Coreceptor in class II MHC-restricted antigen-induced T cell activation (binds to class II MHC molecules); thymocyte development; receptor for HIV
CD5 67 kD; scavenger receptor family T cells; B-1 B cell subset Signaling molecule; binds CD72
CD8α 34 kD; expressed as a homodimer or heterodimer with CD8β Class I MHC–restricted T cells; subset of dendritic cells Coreceptor in class I MHC-restricted antigen-induced T cell activation (binds to class I MHC molecules); thymocyte development
CD8β 34 kD; expressed as a heterodimer with CD8α Ig superfamily Class I MHC–restricted T cells Same as CD8α
CD10 100 kD; type II membrane protein Immature and some mature B cells; lymphoid progenitors, granulocytes Metalloproteinase; unknown function in the immune system
CD11a (LFA-1 α chain) 180 kD; non-covalently linked to CD18 to form LFA-1 integrin Leukocytes Cell-cell adhesion; binds to ICAM-1 (CD54), ICAM-2 (CD102), and ICAM-3 (CD50)
CD11b (Mac-1; CR3) 165 kD; non-covalently linked to CD18 to form Mac-1 integrin Granulocytes, monocytes, macrophages, dendritic cells, NK cells Phagocytosis of iC3b-coated particles; neutrophil and monocyte adhesion to endothelium (binds CD54) and extracellular matrix proteins
CD11c (p150,95; CR4α chain) 145 kD; non-covalently linked to CD18 to form p150,95 integrin Monocytes, macrophages, granulocytes, NK cells Similar functions as CD11b
CD14 53 kD; GPI linked Dendritic cells, monocytes, macrophages, granulocytes Binds complex of LPS and LPS-binding protein and displays LPS to TLR4; required for LPS-induced macrophage activation
CD16a (FcγRIIIA) 50-70 kD; transmembrane protein; Ig superfamily NK cells, macrophages Binds Fc region of IgG; phagocytosis and antibody-dependent cellular cytotoxicity
CD16b (FcγRIIIB) 50-70 kD; GPI linked; Ig superfamily Neutrophils Binds Fc region of IgG; synergy with FcγRII in immune complex–mediated neutrophil activation
CD18 95 kD; non-covalently linked to CD11a, CD11b, or CD11c to form γ 2 integrins Leukocytes See CD11a, CD11b, CD11c
CD19 95 kD; Ig superfamily Most B cells B cell activation; forms a coreceptor complex with CD21 and CD81 that delivers signals that synergize with signals from B cell antigen receptor complex
CD20 35-37 kD; tetraspan (TM4SF) family B cells ? Role in B cell activation or regulation; calcium ion channel
CD21 (CR2; C3d receptor) 145 kD; regulators of complement activation Mature B cells, follicular dendritic cells Receptor for complement fragment C3d; forms a coreceptor complex with CD19 and CD81 that delivers activating signals in B cells; receptor for Epstein-Barr virus
CD22 130-140 kD; Ig superfamily; sialoadhesin family; ITIM in cytoplasmic tail B cells Regulation of B cell activation; adhesion molecule
CD23 (FcεRIIB) 45 kD; C-type lectin Activated B cells, monocytes, macrophages Low-affinity Fcε receptor, induced by IL-4; function is not clear
CD25 (IL-2 receptor α chain) 55 kD; non-covalently associated with IL-2Rβ (CD122) and IL-2Rγ (CD132) chains to form a high-affinity IL-2 receptor Activated T and B cells, regulatory T cells (Treg) Binds IL-2 and promotes responses to low concentrations of IL-2
CD28 Homodimer of 44-kD chains; Ig superfamily T cells (all CD4 + and >50% of CD8 + cells in humans; all mature T cells in mice) T cell receptor for costimulatory molecules CD80 (B7-1) and CD86 (B7-2)
CD29 130 kD; non-covalently linked to CD49a-d chains to form VLA (β 1) integrins T cells, B cells, monocytes, granulocytes Leukocyte adhesion to extracellular matrix proteins and endothelium (see CD49)
CD30 (TNFRSF8) 120 kD; TNFR superfamily Activated T and B cells; NK cells, monocytes, Reed-Sternberg cells in Hodgkin’s disease Not established
CD31 (platelet/endothelial cell adhesion molecule 1, PECAM-1) 130-140 kD; Ig superfamily Platelets, monocytes, granulocytes, B cells, endothelial cells Adhesion molecule involved in leukocyte transmigration through endothelium
CD32 (FcγRII) 40 kD; Ig superfamily; ITIM in cytoplasmic tail; A, B, and C forms are products of different but homologous genes B cells, macrophages, dendritic cells, granulocytes Fc receptor for aggregated IgG; acts as inhibitory receptor that blocks activation signals in B cells and other cells
CD34 105-120 kD; sialomucin Precursors of hematopoietic cells; endothelial cells in high endothelial venules ? Role in cell-cell adhesion
CD35 (type 1 complement receptor, CR1) 190-285 kD (four products of polymorphic alleles); regulator of complement activation family Granulocytes, monocytes, erythrocytes, B cells, follicular dendritic cells, some T cells Binds C3b and C4b; promotes phagocytosis of C3b- or C4b-coated particles and immune complexes; regulates complement activation
CD36 85-90 kD Platelets, monocytes, macrophages, endothelial cells Scavenger receptor for oxidized low-density lipoprotein; platelet adhesion; phagocytosis of apoptotic cells
CD40 Homodimer of 44- to 48-kD chains; TNFR superfamily B cells, macrophages, dendritic cells, endothelial cells Binds CD154 (CD40 ligand); role in T cell–mediated activation of B cells, macrophages, and dendritic cells
CD43 95-135 kD; sialomucin Leukocytes (except circulating B cells) ?Role in cell-cell adhesion
CD44 80->100 kD, highly glycosylated Leukocytes, erythrocytes Binds hyaluronan; involved in leukocyte adhesion to endothelial cells and extracellular matrix
CD45 (Leukocyte common antigen [LCA]) Multiple isoforms, 180-220 kD (see CD45R); protein tyrosine phosphatase receptor family; fibronectin type III family Hematopoietic cells Tyrosine phosphatase that regulates T and B cell activation
CD45R CD45RO:180 kD CD45RA: 220 kD CD45RB: 190-, 205-, and 220-kD isoforms CD45RO: memory T cells; subset of B cells, monocytes, macrophages CD45RA: naive T cells, B cells, monocytes CD45RB: B cells, subset of T cells See CD45
CD46 (Membrane cofactor protein (MCP) 52-58 kD; regulators of complement activation family Leukocytes, epithelial cells, fibroblasts Regulation of complement activation
CD47 47-52 kD; Ig superfamily All hematopoietic cells, epithelial cells, endothelial cells, fibroblasts Leukocyte adhesion, migration, activation; “Don’t eat me” signal to phagocytes
CD49d 150 kD; non-covalently linked to CD29 to form VLA-4 (α 4β 1 integrin) T cells, monocytes, B cells, NK cells, eosinophils, dendritic cells, thymocytes Leukocyte adhesion to endothelium and extracellular matrix; binds to VCAM-1 and MadCAM-1; binds fibronectin and collagens
CD54 (ICAM-1) 75-114 kD; Ig superfamily T cells, B cells, monocytes, endothelial cells (cytokine inducible) Cell-cell adhesion; ligand for CD11aCD18 (LFA-1) and CD11bCD18 (Mac-1); receptor for rhinovirus
CD55 (Decay-accelerating factor [DAF]) 55-70 kD; GPI linked; regulators of complement activation family Broad Regulation of complement activation
CD58 (Leukocyte function–associated antigen 3 [LFA-3]) 55-70 kD; GPI-linked or integral membrane protein Broad Leukocyte adhesion; binds CD2
CD59 18-20 kD; GPI linked Broad Binds C9; inhibits formation of complement membrane attack complex
CD62E E-selectin) 115 kD; selectin family Endothelial cells Leukocyte-endothelial adhesion
CD62L (L-selectin) 74-95 kD; selectin family B cells, T cells, monocytes, granulocytes, some NK cells Leukocyte-endothelial adhesion; homing of naive T cells to peripheral lymph nodes
CD62P (P-selectin) 140 kD; selectin family Platelets, endothelial cells (present in granules, translocated to cell surface on activation) Leukocyte adhesion to endothelium, platelets; binds CD162 (PSGL-1)
CD64 (FcγRI) 72 kD; Ig superfamily; non-covalently associated with the FcR common γ chain Monocytes, macrophages, activated neutrophils High-affinity Fcγ receptor; role in phagocytosis, ADCC, macrophage activation
CD66e (Carcinoembryonic antigen [CEA]) 180-220 kD; Ig superfamily; carcinoembryonic antigen (CEA) family Colonic and other epithelial cells ? Adhesion; clinical marker of carcinoma burden
CD69 23 kD; C-type lectin Activated B cells, T cells, NK cells, neutrophils Binds to and impairs surface expression of S1PR1, thereby promoting retention of recently activated lymphocytes in lymphoid tissues
CD74 (Class II MHC invariant chain [I i]) 33-, 35-, and 41-kD isoforms B cells, dendritic cells, monocytes, macrophages; other class II MHC–expressing cells Binds to and directs intracellular sorting of newly synthesized class II MHC molecules
CD79a (Igα) 33, 45 kD; forms dimer with CD79b; Ig superfamily; ITAM in cytoplasmic tail Mature B cells Required for cell surface expression of and signal transduction by the B cell antigen receptor complex
CD79b (Igβ) 37-39 kD; forms dimer with CD79α; Ig superfamily; ITAM in cytoplasmic tail Mature B cells Required for cell surface expression of and signal transduction by the B cell antigen receptor complex
CD80 (B7-1) 60 kD; Ig superfamily Dendritic cells, activated B cells and macrophages Costimulator for T lymphocyte activation; ligand for CD28 and CD152 (CTLA-4)
CD81 (Target for anti-proliferative antigen 1 [TAPA-1]) 26 kD; tetraspan (TM4SF) T cells, B cells, NK cells, dendritic cells, thymocytes, endothelial cells B cell activation; forms a coreceptor complex with CD19 and CD21 that delivers signals that synergize with signals from the B cell antigen receptor complex
CD86 (B7-2) 80 kD; Ig superfamily B cells, monocytes; dendritic cells; some T cells Costimulator for T lymphocyte activation; ligand for CD28 and CD152 (CTLA-4)
CD88 (C5a receptor) 43 kD; G protein–coupled, 7 membrane–spanning receptor family Granulocytes, monocytes, dendritic cells, mast cells Receptor for C5a complement fragment; role in complement-induced inflammation
CD89 (Fcα receptor [FcαR]) 55-75 kD; Ig superfamily; non-covalently associated with the common FcR γ chain Granulocytes, monocytes, macrophages, T cell subset, B cell subset Binds IgA; mediates IgA-dependent cellular cytotoxicity
CD90 (Thy-1) 25-35 kD; GPI linked; Ig superfamily Thymocytes, peripheral T cells (mice), CD34 + hematopoietic progenitor cells, neurons Marker for T cells; unknown function
CD94 43 kD; C-type lectin; on NK cells, covalently assembles with other C-type lectin molecules (NKG2) NK cells; subset of CD8 + T cells CD94/NKG2 complex functions as an NK cell inhibitory receptor; binds HLA-E class I MHC molecules
CD95 (Fas) Homotrimer of 45-kD chains; TNFR superfamily Broad Binds Fas ligand; delivers signals leading to apoptotic death
CD102 (ICAM-2) 55-65 kD; Ig superfamily Endothelial cells, lymphocytes, monocytes, platelets Ligand for CD11aCD18 (LFA-1); cell-cell adhesion
CD103 (α E integrin subunit) Dimer of 150- and 25-kD subunits; non-covalently linked to β 7 integrin subunit to form α Eβ 7 integrin Intraepithelial lymphocytes, other cell types Role in T cell homing to and retention in mucosa; binds E-cadherin
CD106 (Vascular cell adhesion molecule 1 [VCAM-1]) 100-110 kD; Ig superfamily Endothelial cells, macrophages, follicular dendritic cells, marrow stromal cells Adhesion of cells to endothelium; receptor for CD49dCD29 (VLA-4) integrin; role in lymphocyte trafficking, activation
CD134 (OX40, TNFRSF4) 29 kD; TNFR superfamily Activated T cells Receptor for T cell CD252; T cell costimulation
CD150 (Signaling lymphocyte activation molecule [SLAM]) 37 kD; Ig superfamily Thymocytes, activated lymphocytes, dendritic cells, endothelial cells Regulation of B cell–T cell interactions and lymphocyte activation
CD152 (Cytotoxic T lymphocyte–associated protein 4 [CTLA-4]) 33, 50 kD; Ig superfamily Activated T lymphocytes, regulatory T cells Mediates suppressive function of regulatory T cells; inhibits T cell responses; binds CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells
CD154 (CD40 ligand [CD40L]) Homotrimer of 32- to 39-kD chains; TNFR superfamily Activated CD4 + T cells Activation of B cells, macrophages, and endothelial cells; ligand for CD40
CD158 (Killer Ig-like receptor [KIR]) 50, 58 kD; Ig superfamily; killer Ig-like receptor (KIR) family; ITIMs or ITAMs in cytoplasmic tail NK cells, T cell subset Inhibition or activation of NK cells on interaction with appropriate class I HLA molecules
CD159a (NKG2A) 43 kD; C-type lectin; forms heterodimer with CD94 NK cells, T cell subset Inhibition or activation of NK cells on interaction with class I HLA molecules
CD159c (NKG2C) 40 kD; C-type lectin; forms heterodimer with CD94 NK cells Activation of NK cells on interaction with the appropriate class I HLA molecules
CD162 (P-selectin glycoprotein ligand 1 [PSGL-1]) Homodimer of 120-kD chains; sialomucin T cells, monocytes, granulocytes, some B cells Ligand for selectins (CD62P, CD62L); adhesion of leukocytes to endothelium
CD178 (Fas ligand [FasL]) Homotrimer of 31-kD subunits; TNF superfamily Activated T cells Ligand for CD95 (Fas); triggers apoptotic death
CD206 (Mannose receptor) 166 kD; C-type lectin Macrophages Binds high-mannose–containing glycoproteins on pathogens; mediates macrophage endocytosis of glycoproteins and phagocytosis of bacteria, fungi, and other pathogens
CD244 (2B4) 41 kD; Ig superfamily; CD2/CD48/CD58 family; SLAM family NK cells, CD8 T cells, γδ T cells Receptor for CD148; modulates NK cell cytolytic activity
CD247 (TCR ζ chain) 18 kD; ITAMs in cytoplasmic tail T cells; NK cells Signaling chain of TCR- and NK cell–activating receptors
CD252 (OX40 ligand) 21 kD; TNF superfamily Dendritic cells, macrophages, B cells Ligand for CD134 (OX40,TNFRSF4); costimulates T cells
CD267 (TACI) 31 kD; TNFR superfamily B cells Receptor for cytokines BAFF and APRIL; mediates B cell survival
CD268 (BAFF receptor) 19 kD; TNFR superfamily B cells Receptor for BAFF; mediates B cell survival
CD269 (BCMA [B cell maturation antigen]) 20 kD; TNFR superfamily B cells Receptor for BAFF and APRIL; mediates B cell survival
CD273 (PD-L2) 25 kD; Ig superfamily; structurally homologous to B7 Dendritic cells, monocytes, macrophages Ligand for PD-1; inhibits T cell activation
CD274 (PD-L1) 33 kD; Ig superfamily; structurally homologous to B7 Leukocytes, other cells Ligand for PD-1; inhibits T cell activation
CD275 (ICOS ligand) 60 kD; Ig superfamily; structurally homologous to B7 B cells, dendritic cells, monocytes Binds ICOS (CD278); T cell costimulation
CD278 (ICOS [inducible costimulator]) 55-60 kD; Ig superfamily; structurally homologous to CD28 Activated T cells Binds ICOS-L (CD275); T cell costimulation
CD279 (PD1) 55 kD; Ig superfamily; structurally homologous to CD28 Activated T and B cells Binds PD-L1 and PD-L2; inhibits T cell activation
CD314 (NKG2D) 42 kD; C-type lectin NK cells, activated CD8 + T cells, NK-T cells, some myeloid cells Binds MHC class I, and the class I-like molecules MIC-A, MIC-B, Rae1, and ULBP4; role in NK cell and CTL activation
CD357 (GITR) 26 kD; TNFR superfamily CD4 + and CD8 + T cells, Treg ? Role in T cell tolerance/Treg function
CD363 (S1PR1 [type 1 sphingosine-1-phosphate receptor 1]) 42.8 kD; G protein–coupled, 7 membrane–spanning receptor family Lymphocytes, endothelial cells Binds sphingosine 1-phosphate and mediates chemotaxis of lymphocytes out of lymphoid organs
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