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Old 10-02-2014
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Default Type I, II and III RPGN's

How to remember what is Type I, II and III. It's confusing most of the times those descriptions of lumpy bumpy, pauci immune.

Type 1 remember it is linear 1 is simple no curves, loops, bumps.
Type 2, look how two is, it has got lumps and bumps.
Type 3, is pauci immune, now we have got two m's in "immune" just rotate the three it becomes an m.
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Old 10-08-2014
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Originally Posted by Panmedic View Post
How to remember what is Type I, II and III. It's confusing most of the times those descriptions of lumpy bumpy, pauci immune.

Type 1 remember it is linear 1 is simple no curves, loops, bumps.
Type 2, look how two is, it has got lumps and bumps.
Type 3, is pauci immune, now we have got two m's in "immune" just rotate the three it becomes an m.
Type 1 RPGN is Goodpasture's. So you'll have Hemoptysis AND Hematuria. Your second big clue is the Linear Deposits on IF. The way I think of the Linear IF picture is since it's only Type II Hypersensitivity, that means the BM is only collecting IgG + C3 as opposed to Post-Strep GN (Type III Hypersensitivity) where you have IgG + C3 + Ag... There's more trying to get through the BM and it causes the lumpy-bumpy appearance, they can't all get through so they collect there. Of all the Nephritic Diseases, Goodpasture's is the only one that's Type II Hypersensitivity (2 = 2 "o's" in gOOdpastures).

Type 2 RPGN is most commonly seen in Post Strep GN and Diffuse Prolif GN -> if you think about it, Rapid Progressive is not only in the same category as these two but it's the progressive next step toward Renal Failure.

Type 3 RPGN is your Vasculitis Diseases, so that's not only different than any of the other Renal Diseases but they give unique extra-renal symptoms. Take Wegener's for instance, it'll present with Nasopharynx, Resp AND Renal symptoms.
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