barbiturates contraindicated in porphyria patients - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     57,689 Members     253,440 Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 07-14-2011
yasirsattar75's Avatar
USMLE Forums Guru
 
Steps History: Not yet
Posts: 399
Threads: 51
Thanked 263 Times in 111 Posts
Reputation: 273
Biochemistry barbiturates contraindicated in porphyria patients

barbiturate indduces p450 enzyme system and increases the formation of heme? and as in porphyrias there is enzyme deficiency such as urobillinogen decarboxylase and porphobillinogen decarboxylase etc .. so more heme formation provokes porphyrias .. can anyone explain more plz ....
Reply With Quote Quick reply to this message



  #2  
Old 07-14-2011
Mashee's Avatar
USMLE Forums Addict
 
Steps History: 1+CK+CS
Posts: 148
Threads: 9
Thanked 97 Times in 61 Posts
Reputation: 107
Default

Ya sure it's cuz the p450 enzymes contain heme in their structure.. So if u have a deficiency in one of the enzymes of the heme pathway, and u take a barbiturate it will increase sythesis of p450 which will result in accumulation of the substrates that come before the enzmes deficient in the heme pathway..
Reply With Quote Quick reply to this message
The above post was thanked by:
Panmedic (03-31-2014), yasirsattar75 (07-14-2011)



Reply

Tags
Biochemistry-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Barbiturates, Alcohol, and Benzodiazepines schiwei USMLE Step 1 Mnemonics 2 12-15-2010 07:37 AM
'HAM' is Contraindicated for Succinylcholine! anila USMLE Step 1 Mnemonics 0 12-08-2010 09:56 AM
Which NSAID is contraindicated in Gout mtoi USMLE Step 1 Forum 2 11-21-2010 04:04 PM
Porphyria questions in CK exam geof1 USMLE Step 2 CK Forum 3 03-06-2010 01:22 PM
Acute Intermittent Porphyria Dr. N Elham USMLE Step 1 Forum 1 12-12-2009 05:05 AM

RSS Feed
Find Us on Facebook

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)