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Old 01-05-2010
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Drug First Aid's Clindamycin mechanism

According to First Aid, clindamycin blocks peptide bond formation.

But when I read Kaplan's pharmaco, it says clindamycin acts just like macrolides, which is to inhibit translocation of peptidyl-tRNA. Only chloramphenicol is involved in disturbing the "peptide bond formation" event in bacterial protein synthesis.

What do you guys think? Does clindamycin act both during the peptide bond formation stage, and also the translocation stage?
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tomymajor (01-06-2010)



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Old 01-06-2010
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check this article
http://sitemaker.umich.edu/mc3/clindamycin

they mentioned that it works like macrolides on the translocation step of protein synthesis.
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lemontea88 (01-07-2010)
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Old 01-06-2010
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clindamycin acts lyk macrolides on translocation.... acc to katzung review as well.....
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Old 01-07-2010
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Also have a look here
Antibacterial antibiotics Mechanism of action
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