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Old 07-15-2011
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Question ACTH inhibiton by ADH!

In UW it says that ACTH is inhibited by cortisol and "arginine vasopressin" from the hypothalamus. I suppose that this " arginine vasopressin" is ADH, then why ADH can unhibit ACTH?

Please correct me if these two vasopressin are not the same, and also explain why arginine vasopressin can inhibit cortisol.

Thank you for your patience.
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Old 07-15-2011
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CRH is the principal stimulus for ACTH secretion, but arginine vasopressin (AVP) is able to potentiate CRH-mediated secretion. In this case, AVP acts through the V1B receptor to activate protein kinase C.
Physical stresses increase ACTH and cortisol secretion, again through central actions mediated via CRH and AVP.
Other reported ACTH secretagogues, including angiotensin II, cholecystokinin, atrial natriuretic factor, and vasoactive peptides, probably act to modulate the CRH control of ACTH secretion.

ACTH inhibiton by ADH!-feedback_cortisol.jpeg
click image to enlarge

Reference: Williams Textbook of Endocrinology, 12th ed. 2011
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Old 07-15-2011
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I want to correct myself

ADH stimulates ACTH secretion. However, there is no clear feedback loop between cortisol and vasopressin.
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