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  #1  
Old 07-18-2011
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Microscope Dystrophic vs Metastatic Calcifications

A 60-year-old woman with breast cancer and widespread bony metastases is found to have calcification of multiple organs. The calcifications are best described as


(A) dystrophic with decreased serum calcium.
(B) dystrophic with increased serum calcium.
(C) metastatic with decreased serum calcium.
(D) metastatic with increased serum calcium.
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Old 07-18-2011
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Default D

(D) metastatic with increased serum calcium.
I think in Dystrophic the calcium level is normal.
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i would go with answer D
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Old 07-18-2011
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Answer d,mets w/increase calcium
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Old 07-18-2011
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d) metastatic w. increased Ca, mechanism - oseolysis due to PGE; EGF; TNF; IL-1;IL-6 osteoclast stimulating activity (Goljan audio).
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Old 07-18-2011
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idk can anybody explain all the options after answering it
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Old 07-18-2011
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Default D

i think it is D
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Old 07-18-2011
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i think its D. metastatic calcification with increased calcium level.

missed ur posts Bebix
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Old 07-18-2011
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i think its D. metastatic calcification with increased calcium level.

missed your post Bebix
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Old 07-18-2011
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I'm thinking that the answer is d?
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Old 07-19-2011
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D! its hypercalcemia due to malignancy
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  #12  
Old 07-19-2011
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Correct Answer

I wud go wid D
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Old 07-19-2011
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i agree with D
dystrophic is deposition of calcium in necrotic tissue.
metastatic is deposition of calcium in normal tissue.
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Correct Answer correct answer

The answer is D.

Metastatic calcification, or deposition of calcium in previously normal tissue, is caused by hypercalcemia. In this patient, tumor metastases to bone with increased osteolytic activity caused mobilization of calcium and phosphate, resulting in hypercalcemia. Metastatic calcification should be contrasted with dystrophic calcification, in which the serum calcium concentration is normal and previously damaged tissues are the sites of deposition.
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  #15  
Old 07-20-2011
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Quote:
Originally Posted by star123 View Post
i agree with D
dystrophic is deposition of calcium in necrotic tissue.
metastatic is deposition of calcium in normal tissue.
The mnemonic I used

Dystropic = Damaged/Degenerating tissue
Metastatic = Metabolic disorder
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Old 09-14-2012
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"D" seems to be the correct answer for this question, however it is worth noting that both Dystrophic and Metastatic Calcification can be seen in breast cancer patients. Calcifications seen in the breast tissue on a Mammogram are Dystrophic, but Diffuse Skeletal Metastasis secondary to Breast Cancer can cause hypercalcemia that is associated with the multi-organ calcification.
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Old 09-14-2012
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Quote:
Originally Posted by bebix View Post
A 60-year-old woman with breast cancer and widespread bony metastases is found to have calcification of multiple organs. The calcifications are best described as


(A) dystrophic with decreased serum calcium.
(B) dystrophic with increased serum calcium.
(C) metastatic with decreased serum calcium.
(D) metastatic with increased serum calcium.
d is the ans becz in malginancy prh(not sure abt harmone name) is released which results in increase PTH secreation which casuses increase in CALcium level which leads to calcification of organs
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