Morphologic myocardial findings indicator of irreversible injury. - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 07-18-2011
bebix's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,357
Threads: 194
Thanked 3,268 Times in 881 Posts
Reputation: 3278
Heart Morphologic myocardial findings indicator of irreversible injury.

A 56-year-old man dies 24 hours after the onset of substernal chest pain radiating down his left arm to the ulnar aspect of his fingertips. Which of the following morphologic myocardial findings is an indicator of irreversible injury?

(A) Cell blebs
(B) Depletion of glycogen
(C) Mitochondrial swelling
(D) Myelin figures
(E) Pyknotic nuclei
Reply With Quote Quick reply to this message
The above post was thanked by:
pass7 (07-18-2011), struggle (07-19-2011), tootsie (07-18-2011)



  #2  
Old 07-18-2011
mle2resident's Avatar
USMLE Forums Veteran
 
Steps History: 1 + CS
Posts: 252
Threads: 51
Thanked 185 Times in 94 Posts
Reputation: 195
Default ?C..

Am confused btn C and E... But my final choice ll be C..
Reply With Quote Quick reply to this message
  #3  
Old 07-18-2011
USMLE Forums Scout
 
Steps History: Not yet
Posts: 10
Threads: 0
Thanked 7 Times in 5 Posts
Reputation: 17
Default

I would say C. Mitochondrial

I just remember that the irreversible situations have to do with:
1. Nuclear damage- 1st sign of irreversible death
2. Lysosomes- ex. I-cell Disease
3. Mitochondria- ex. Leber's and Leigh's syndrome.
Reply With Quote Quick reply to this message
 
  #4  
Old 07-18-2011
USMLE Forums Master
 
Steps History: Not yet
Posts: 674
Threads: 264
Thanked 963 Times in 394 Posts
Reputation: 973
Send a message via Yahoo to ricko335
Default

MITOCHONDRIAL SWELLING


If perfusion is not restored within 4060 minutes, an irreversible stage of injury characterized by diffuse mitochondrial swelling, damage to the cell membrane, and marked depletion of glycogen begins
Reply With Quote Quick reply to this message
The above post was thanked by:
docmd11 (07-19-2011)
  #5  
Old 07-18-2011
tootsie's Avatar
USMLE Forums Guru
 
Steps History: Not yet
Posts: 433
Threads: 16
Thanked 284 Times in 199 Posts
Reputation: 294
Default

i think it's C. For a moment i thought it was E.
Reply With Quote Quick reply to this message
  #6  
Old 07-18-2011
bebix's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,357
Threads: 194
Thanked 3,268 Times in 881 Posts
Reputation: 3278
Correct Answer correct answer

Quote:
Originally Posted by bebix View Post
A 56-year-old man dies 24 hours after the onset of substernal chest pain radiating down his left arm to the ulnar aspect of his fingertips. Which of the following morphologic myocardial findings is an indicator of irreversible injury?

(A) Cell blebs
(B) Depletion of glycogen
(C) Mitochondrial swelling
(D) Myelin figures
(E) Pyknotic nuclei
Well, the correct answer is E) Pyknotic nuclei

Early stages of hypoxic injury affects the mithochondria with resultant decresed oxidative phosphorilation and ATP synthesis. Consecuences are failure of pump: increased NA+ and water, cellular swelling: hydropic change, swelling RE and mithochondria.

Irreversible injury:
- Release of cytochrome c
- Nuclear changes = Pyknosis, Karyorrhexis and Karyolysis

This question is from BRS Phatology
Reply With Quote Quick reply to this message
The above post was thanked by:
bandar (07-18-2011), docmd11 (07-19-2011), jahn77 (07-18-2011), mle2resident (07-18-2011), pass7 (07-18-2011), struggle (07-19-2011)
  #7  
Old 07-18-2011
USMLE Forums Addict
 
Steps History: Not yet
Posts: 140
Threads: 5
Thanked 118 Times in 66 Posts
Reputation: 128
Default

I was thinking c as well, I always mess up these irreversible and reversible cell injury questions. Really need work on them...
Reply With Quote Quick reply to this message
  #8  
Old 07-19-2011
axax's Avatar
USMLE Forums Addict
 
Steps History: 1+CK+CS
Posts: 115
Threads: 3
Thanked 267 Times in 41 Posts
Reputation: 277
Default

(E) Pyknotic nuclei- nuclear change = cell death
__________________
Learning is like to row your boat upstream, if you stop learning, you will be pushed back by the current.
Reply With Quote Quick reply to this message



Reply

Tags
Cardiovascular-, Pathology-, Step-1-Questions

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
The marker findings in Down syndrome bebix USMLE Step 2 CK Forum 3 05-28-2011 10:36 AM
Indicator of alcohol use schiwei USMLE Step 1 Mnemonics 0 12-14-2010 02:31 PM
Irreversible Steps of Glycolysis FreakingOut USMLE Step 1 Forum 3 05-17-2010 11:30 AM
Pericarditis Findings jackat1000 USMLE Step 1 Mnemonics 2 03-19-2010 05:59 AM
CSF findings in Fungal Infections panam04 USMLE Step 1 Forum 4 11-19-2009 07:30 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)