11 bHydroxysteroid Dehydorgenase not only on adrenal cortex but also in renal cells! - USMLE Forums
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Old 07-19-2011
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Listening 11 bHydroxysteroid Dehydorgenase not only on adrenal cortex but also in renal cells!

I think it is a good point to share becuase I notice until my second lecture on Endocrine Physiology.
Cortisol has high affinity for mineralocorticoid receptors and late distal tubule and collecting ducts on kidney (just as high as Aldosterone) and circulating levels of Cortisol are higher than Aldosterone.
So how Cortisol does not compete with Aldosterone on distal tubules and collecting ducts?
Renal cells contain 11 bHydroxysteroid Dehydorgenase (also found in adrenal cortex) and converts Cortisol to Cortisone...and Cortisone has very low affinity for mineralocorticoid receptors...
This way cortisol is effectively inactivated in mineralocorticoid tissue and let aldosteone do its job!!
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The above post was thanked by:
samstar (07-19-2011)



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Old 07-19-2011
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Smile thnks

thnks for the info......it was new to me
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