Therefore, in any metabolic acidosis you'll have increased anion gap unless the chloride compensates for the depressed bicarb.
Therefore, any normal anion gap metabolic acidosis is essentially hyperchloremic metabolic acidosis. See normal anion gap mnemonic thread
In proximal renal tubular acidosis you have failure of bicarbonate reabsorption and this will be compensated by chloride reabsorption to maintain neutrality across the renal tubule membrane. See this thread for a similar issue
Therefore, in any metabolic acidosis you'll have increased anion gap unless the chloride compensates for the depressed bicarb.
Therefore, any normal anion gap metabolic acidosis is essentially hyperchloremic metabolic acidosis. See normal anion gap mnemonic thread
In proximal renal tubular acidosis you have failure of bicarbonate reabsorption and this will be compensated by chloride reabsorption to maintain neutrality across the renal tubule membrane. See this thread for a similar issue
Just wanted to add here that in RTA you also have something called the urine anion gap.
The urine anion gap = (Na+) - Cl-
In RTA because we fail to excrete NH4Cl then we have low chloride in urine the urine anion gap is positive unlike the other causes of normal anion gap acidosis (such as diarrhea) where have a negative urine anion gap
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