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Old 01-13-2010
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Question Dexamethasone Suppression!

in c/o dexamethasone treatment : levels of glucocorticoid in the body, rise and there is negative feedback causing the ACTH to reduce. so the endogenous sr. cortisol levels fall? kindly explain. thanks.
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Old 01-13-2010
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What is it that you don't understand?
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Old 01-13-2010
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Quote:
Originally Posted by getting99 View Post
What is it that you don't understand?
I think hipocampus is wondering how come we have low cortisol while in fact we just gave dexamethasone which is also a steroid!
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Old 01-13-2010
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dexamethason suppress ACTH and so then we measure serum cortisol level not serum dexamethasone level.
Important pharmacologic property of dexa to remember is that it has zero mineralocorticoid activity.
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Old 01-13-2010
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Frankly I didn't get the question either.. but dexamethazone is not detected in laboratory cortisol assays if that's what you are asking about, this is the reason it is the durg used in the test, and the naming of the test.
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