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Old 07-25-2011
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Question What is the effect of anabolic steroid on bone?

I would really appreciate if anyone can help me out here.

I know anabolic steroids can be used to treat osteoporosis.

But then they cause decreased estrogen in women (and decreased testosterone in men). By doing so, they can increase bone loss which will lead to osteoporosis.

I know I am missing something here. I would be thankful if someone can show me where I am going wrong.

If a woman body builder is abusing anabolic steroid and has amenorrhea, should I consider osteoporosis too?

Thanks.
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Old 07-25-2011
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Yes, definitely, effects of not having estrogen will lead to osteoporosis.

But this would be due to down regulation of the receptors when using it with exogenous steroids.

As for the treatment, I think when you are post menopausal you wouldn't have hormones, so giving steroids will increase your steroids, preventing bone loss.
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Old 07-25-2011
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Actually, No having estrogen lead to Downregulation of IL1 aka Osteoclastic Regulator factor, Which is responsible for the break down of bone, when you dont have estrogen, you Leave IL1 without his "check" hormone, which lead to MORE break down of Bone!... That's why you get Osteoporosis on Menopause Womens.

Another point is, When you take Steroid, actually you are Increasing Osteoclastic Activity and Decreasing Osteoblastic activity, that's how you get osteoporosis on Anabolic Steroid.

Hope it helps... =)
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Quote:
Originally Posted by rulz View Post
Actually, No having estrogen lead to Downregulation of IL1 aka Osteoclastic Regulator factor, Which is responsible for the break down of bone, when you dont have estrogen, you Leave IL1 without his "check" hormone, which lead to MORE break down of Bone!... That's why you get Osteoporosis on Menopause Womens.

Another point is, When you take Steroid, actually you are Increasing Osteoclastic Activity and Decreasing Osteoblastic activity, that's how you get osteoporosis on Anabolic Steroid.

Hope it helps... =)
That's odd because anabolic steroids can be USED for the TREATMENT of Osteoporosis.

If you increase Osteoclastic Activity you will make things worse.

Steroids are basically Testosterone,which will aromatize to Estrogen, so you will inturn prevent IL1 Activity.
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Quote:
Originally Posted by patelMD View Post
That's odd because anabolic steroids can be USED for the TREATMENT of Osteoporosis.

If you increase Osteoclastic Activity you will make things worse.

Steroids are basically Testosterone,which will aromatize to Estrogen, so you will inturn prevent IL1 Activity.
My bad, I misunderstood the concept for a sec, Anabolic steroid are different from Steroid.

Yes, They are used to treat osteoporosis, in fact if you give testosterone to a woman they will experience virilization: increased growth of androgen-sensitive hair (pubic, beard, chest, and limb hair), increased vocal cord size, deepening the voice, increased libido, growth of clitoris, etc.

"Anabolic Steroid" tend to decrease the levels of cortisol in the body, therefore decreasing "Steroid" activity, which will block the pathway that i already explain ( sorry, at first i though we were talking about "STEROID" not anabolic steroid".

In the same way, they will block Muscle wasting, therefore, making "people who take it" increase they muscle mass, therefore decreasing the catabolism effect ( the protein loss).

Anabolic steroid exert their effects by increased protein synthesis from amino acids, increased appetite, increased bone remodeling and growth, and stimulation of bone marrow, which increases red blood cells.

So, to answer his question, Yes its true they can reduce Testosterone because they cause atrophic over the testes ( that can lead to osteoporosis) because "You are not using then" You are just injecting exogenous. But in the meantime they block Steroid which are the one who cause osteporosis. ( Cortisol ).
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