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#1
07-25-2011
 USMLE Forums Addict Steps History: Not yet Posts: 151 Threads: 39 Thanked 52 Times in 29 Posts Reputation: 62
Liver and Renal diseases and Volume of distribution

In liver and renal diseases,

Maintenance dose decreases,

Why when Vd changes which is present in the equation for loading dose??? but even then it remains unchanged???

#2
07-25-2011
 USMLE Forums Addict Steps History: Not yet Posts: 96 Threads: 5 Thanked 68 Times in 36 Posts Reputation: 78

I'm not really sure, but here are my thoughts on that.

Loading dose is a function of volume of distribution, which in turn depends on protein binding capacity of plasma. And PBC is always greater than the drug concentration, so I guess the level of albumin cannot fall that low that the drug concentration is higher and then Vd will be affected. Also, Vd=Dose/concentration at time zero. Both parameters don't change.

Maintenance dose is a function of Cl, which decreases in renal diseases.

 Tags Pharmacology-

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