Liver and Renal diseases and Volume of distribution - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 07-25-2011
USMLE Forums Addict
 
Steps History: Not yet
Posts: 151
Threads: 39
Thanked 52 Times in 29 Posts
Reputation: 62
Drug Liver and Renal diseases and Volume of distribution

In liver and renal diseases,

loading dose remains unchanged ,
Maintenance dose decreases,

Why when Vd changes which is present in the equation for loading dose??? but even then it remains unchanged???
Reply With Quote Quick reply to this message



  #2  
Old 07-25-2011
USMLE Forums Addict
 
Steps History: Not yet
Posts: 96
Threads: 5
Thanked 68 Times in 36 Posts
Reputation: 78
Default

I'm not really sure, but here are my thoughts on that.

Loading dose is a function of volume of distribution, which in turn depends on protein binding capacity of plasma. And PBC is always greater than the drug concentration, so I guess the level of albumin cannot fall that low that the drug concentration is higher and then Vd will be affected. Also, Vd=Dose/concentration at time zero. Both parameters don't change.

Maintenance dose is a function of Cl, which decreases in renal diseases.
Reply With Quote Quick reply to this message



Reply

Tags
Pharmacology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Normal Gaussian Distribution rulz USMLE Step 1 Forum 20 03-05-2012 03:18 PM
Liver disease that does not need a Liver Biopsy? FSUSTC USMLE Step 2 CK Forum 7 04-27-2011 06:07 AM
some pearls of renal tubular diseases jaiparkash USMLE Step 2 CK Bits & Pieces 0 03-09-2011 12:01 AM
Question Distribution for Step 1? noone_123i USMLE Step 1 Forum 1 12-16-2010 02:13 AM
question distribution in step2 ck.. usmleguy USMLE Step 2 CK Forum 1 11-15-2010 09:01 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)